PYRIDYLHYDRAZIDE-BASED COMPOUND AND ANTIPHLOGISTIC CONTAINING IT

Title:

PYRIDYLHYDRAZIDE-BASED COMPOUND AND ANTIPHLOGISTIC CONTAINING IT

Document Type and Number:

Japanese Patent JPS58198469

Kind Code:

A

Abstract:

NEW MATERIAL:A pyridylhydrazide-based compound shown by the formula I (X is halogen; R is methyl which may be replaced with halogen).

EXAMPLE: 2-(5-Trifluoromethyl-6-chloro-2-pyridyl)trifluoroacethydrazide.

USE: Useful as an active ingredient for an antiphlogistic.

PROCESS: For example, a trifluoromethyl-substituted pyridyl-hydrazine-based compound shown by the formula II is reacted with a compound shown by the formula III in the presence of a solvent such as methylene chloride, ether, pyridine, etc. at ≤room temperature for 0.5W10hr, to give a compound shown by the formula I . Or, the compound shown by the formula II is obtained by reacting a trifluoromethyl-substituted-2-halogenopyridine with hydrazine hydrate in the presence of an alcohol solvent such as preferably ethanol, etc. to give the compound shown by the formula I .

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Inventors:

MORI HIROYUKI
HAGA TAKAHIRO
YAMADA SHIYUUITSU
FUJIKAWA NOBORU
NAKAJIMA TOSHIO
OOSHIMA TAKESHI

Application Number:

JP8124782A

Publication Date:

November 18, 1983

Filing Date:

May 14, 1982

Export Citation:

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Assignee:

ISHIHARA SANGYO KAISHA

International Classes:

C07D213/76; A61K31/44; A61K31/4402; A61K31/4418; A61P29/00; (IPC1-7): A61K31/44; C07D213/76

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