Title:
ピロロ[2,3-b]ピリジン化合物、該ピロロ[2,3-b]ピリジン化合物を合成するために用いられるアザインドール化合物、それらの製造方法、及びそれらの使用
Document Type and Number:
Japanese Patent JP2010518153
Kind Code:
A
Abstract:
Pyrimidin-4-yl-1H-pyrrolo[2,3-b]pyridine compounds (I) and their salts are new. Pyrimidin-4-yl-1H-pyrrolo[2,3-b]pyridine compounds of formula (I) and their salts are new. R 11-10C alkoxy (optionally substituted), halo, 1-10C alkyl, , 1-10C fluoroalkoxy, 1-10C alkoxy-10C alkoxy, 5-8C cycloalkoxy, -OH, -OCOR a, -CN, -NO 2, -SR a, -NR aR b, -NHCOR a, -NHSO 2R a, -NHCONR aR b, NHCO 2R a, phenyl, aryl or heteroaryl; R 2H, R 1 or halo; R 3H, -SO 2R a, -COR a or alkyl; and R 4>H or NH 2; either R a, R balkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkylalkynyl, heterocycloalkyl, heteocycloalkylalkyl or heterocycloalkylalkenyl (all optionally substituted) or H; or NR aR bheterocycle (optionally substituted by pyrrolidinyl, piperidinyl, piperazinyl or morpholinyl). Independent claims are included for: (1) the preparation of (I); and (2) a 1H-pyrrolo[2,3-b]pyridine compound of formula (II). [Image] [Image] ACTIVITY : Cytostatic; Neuroprotective; Nootropic; Nephrotropic; Antidiabetic; Antiinflammatory. MECHANISM OF ACTION : Protein kinase inhibitor.
Inventors:
Meyer Laurent
Joseph Benoit
Rigel Francois
Marche Bernard
Joseph Benoit
Rigel Francois
Marche Bernard
Application Number:
JP2009549445A
Publication Date:
May 27, 2010
Filing Date:
February 14, 2008
Export Citation:
Assignee:
Center National Dolchersche Scientific
UNIVERSITE CLAUDE BERNARD LYON 1
Universite Pierre Emery Curie (Paris 6)
UNIVERSITE CLAUDE BERNARD LYON 1
Universite Pierre Emery Curie (Paris 6)
International Classes:
C07D471/04; A61K31/506; A61P3/10; A61P13/12; A61P25/28; A61P29/00; A61P33/00; A61P35/00; A61P35/02; A61P43/00
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki