Title:
β-カテニンを調節するためのRNAアンタゴニスト化合物
Document Type and Number:
Japanese Patent JP2010524486
Kind Code:
A
Abstract:
The invention relates to oligomer compounds (oligomers), which target beta-catening mRNA in a cell, leading to reduced expression of beta-catenin. Reduction of beta-catenin expression is beneficial for a range of medical disorders, such as hyperproliferative disorders, such as cancer. The invention provides therapeutic compositions comprising oligomers and methods for modulating the expression of beta-catenin using said oligomers, including methods of treatment.
Inventors:
Worm, Yespel
Application Number:
JP2010504745A
Publication Date:
July 22, 2010
Filing Date:
April 30, 2008
Export Citation:
Assignee:
SANTARIS PHARMA A/S
ENZON PHARMACEUTICALS, INC.
ENZON PHARMACEUTICALS, INC.
International Classes:
C12N15/09; A61K31/713; A61P35/00; C12N15/113
Domestic Patent References:
| JP2006507841A | 2006-03-09 |
Foreign References:
| WO2001000872A1 | 2001-01-04 | |||
| WO2003031937A2 | 2003-04-17 |
Other References:
J THORAC CARDIOVASC SURG, vol. 127, JPN6013012194, 2004, pages 92 - 98, ISSN: 0002482593
CANCER RES, vol. 61, JPN6013012197, 2001, pages 6563 - 6568, ISSN: 0002482594
J SURG RES, vol. 101, JPN6013012199, 2001, pages 16 - 20, ISSN: 0002482595
EUR J CANCER, vol. 40, JPN6013012201, 2004, pages 1441 - 1452, ISSN: 0002482596
ANN SURG ONCOL, vol. 12, no. 9, JPN6013012203, 2005, pages 733 - 742, ISSN: 0002482597
CANCER RES, vol. 61, JPN6013012197, 2001, pages 6563 - 6568, ISSN: 0002482594
J SURG RES, vol. 101, JPN6013012199, 2001, pages 16 - 20, ISSN: 0002482595
EUR J CANCER, vol. 40, JPN6013012201, 2004, pages 1441 - 1452, ISSN: 0002482596
ANN SURG ONCOL, vol. 12, no. 9, JPN6013012203, 2005, pages 733 - 742, ISSN: 0002482597
Attorney, Agent or Firm:
Yanagita Seiji
Go Sakuma
Go Sakuma