Title:
慢性創傷管理における活性酸素種の減少
Document Type and Number:
Japanese Patent JP2006511585
Kind Code:
A
Abstract:
Reactive oxygen species associated with a wound are modulated through treatment of the wound with a solution of metal ions selected from the group consisting of potassium ions, zinc ions, calcium ions and rubidium ions, at a pH of between about 5 and about 7. Preferably, citric acid is employed to adjust the pH. Application of the extract to a wound exhibiting superoxide anions has been found to be effective in the treatment of these wounds through the reduction of the level of superoxide anions. Moreover, treatment of partial thickness excision wounds as well as contact burn wounds with the present composition has been found to improve epithelialization of these wounds. In addition to the antioxidant activity of the present invention, treatment of the wound employing the present composition produces inhibitory effects on ROS production by human PMNs and on human complement activation, and therefore, is further beneficial in chronic wound management.
Inventors:
Stephen H. Monroe
Hans Hookestra
Ah Ye Ye van den berg
Hans Hookestra
Ah Ye Ye van den berg
Application Number:
JP2004563981A
Publication Date:
April 06, 2006
Filing Date:
December 23, 2003
Export Citation:
Assignee:
Greystone Medical Group, Inc.
International Classes:
A61K33/14; A61K9/08; A61K33/24; A61K33/30; A61K33/32; A61K47/04; A61K47/12; A61P17/02; A61P43/00
Domestic Patent References:
| JPH08503462A | 1996-04-16 | |||
| JPS60239421A | 1985-11-28 |
Other References:
JPN6010028783, 医薬品添加物事典, 1994, 第１版, ｐ．３５５, 株式会社薬事日報社
Attorney, Agent or Firm:
Kyousei Tamura
Nagatoshi Shinagawa
Nagatoshi Shinagawa