不斉アリル化、アルドール、およびタンデムアルドールおよびアリル化反応のための試薬

Japanese Patent JP2005519118

A

A new class of reagents and method of use of the reagents in the reaction of the reagents with electrophilic compounds. The invention in one embodiment is directed to a method for the formation of an alcohol of the formula (I). The method includes reacting a reagent of the formula (II) with an aldehyde of the formula R10CHO to form the alcohol. X3 is one of O and C(R4)(R5). Each of X1 and X2 is independently O or N-R. Each of Ca and Cb is independently an achiral center, an (S) chiral center or an (R) chiral center. Ra and Rb are (i) each independently C1-10 alkyl, C6-10 aryl or C3-9 heteroaryl, or (ii) taken together to form a C3-C4 alkylene chain which together with Ca and Cb forms a 5-membered or 6-membered aliphatic ring. Rc and Rd are each independently hydrogen, C1-10 alkyl, C6-10 aryl or C3-9 heteroaryl. R is C1-10 alkyl, C6-10 aryl or C3-9 heteroaryl. Each of R1, R2, R3, R4, R5 is independently hydrogen, C1-C10 alkyl, C6-10 aryl, C3-9 heteroaryl, C1-10 alkoxy, C6-10 aryloxy, C1-10 dialkylamino, C1-10 alkyl-C6-10 arylamino, C1-10 diarylamino, or halogen. R6 is halogen, hydrogen, C1-10 alkyl, C6-10 aryl, C3-9 heteroaryl, C1-10 alkoxy, C6-10 aryloxy, C1-10 alkyl-C6-10 arylamino, C1-10 diarylamino, OSO2CF3 or SR. R10 may be C1-10 alkyl, C6-10 aryl, or C3-9 heteroaryl.

James El Leighton
James Kinnail
One Shaorun

JP2003573002A

June 30, 2005

March 03, 2003

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The Trustees of Columbia University in the City of New York

C07C33/14; C07C33/20; C07C41/30; C07C41/56; C07C43/178; C07C43/23; C07C241/02; C07C241/04; C07C29/38; C07C243/32; C07F7/02; C07F7/04; C07F7/08; C07F7/10; C07F7/12; C07F7/18; C07C243/28; (IPC1-7): C07F7/08; C07C29/38; C07C33/14; C07C33/20; C07C41/56; C07C43/178; C07C241/02; C07C243/32; C07F7/10

Kosaku Sugimura
Kazuaki Takami
Hiroshi Tokunaga
Shiro Fujitani
Kiyoshi Kuruma
Kazuyuki Tomita

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