Title:
ミッシングタンパク質の小分子模倣体を用いた生理機能の回復
Document Type and Number:
Japanese Patent JP6796581
Kind Code:
B2
Abstract:
Disclosed are methods for treating a disease or condition characterized by decreased expression or reduced function of an ion channel, comprising administering to a subject in need thereof a therapeutically effective amount of a pore-forming polyene macrolide or pore-forming derivative thereof. For example, the pore-forming polyene macrolide may be amphotericin B (AmB), nystatin, or natamycin. The methods can be used to treat cystic fibrosis.
Inventors:
Burke, martin dee
Siophi, Alexander G
Diaz, Katrina A
Ho, jennifer
Guriro, Anthony S
Siophi, Alexander G
Diaz, Katrina A
Ho, jennifer
Guriro, Anthony S
Application Number:
JP2017518434A
Publication Date:
December 09, 2020
Filing Date:
November 03, 2015
Export Citation:
Assignee:
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
International Classes:
A61K31/7048; A61K9/12; A61P3/12; A61P7/00; A61P9/00; A61P21/02; A61P25/02; A61P25/06; A61P25/08; A61P39/02; A61P43/00
Other References:
American Journal of Respiratory Cell and Molecular Biology,2008年,Vol.38,pp.423-434
J.Clin.Invest.,1996年,Vol.97,No.3,pp.664-671
Biochimica et Biophysica Acta,1995年,Vol.1268,pp.50-58
J.Clin.Invest.,1996年,Vol.97,No.3,pp.664-671
Biochimica et Biophysica Acta,1995年,Vol.1268,pp.50-58
Attorney, Agent or Firm:
Hiroshi Higuchi