Title:
CYP24の複製およびその使用
Document Type and Number:
Japanese Patent JP4790127
Kind Code:
B2
Abstract:
This invention pertains to the discovery that an amplification of the CYP24 gene or an increase in CYP24 activity is a marker for the presence of, progression of, or predisposition to, a cancer (e.g., breast cancer). Using this information, this invention provides methods of detecting a predisposition to cancer in an animal. The methods involve (i) providing a biological sample from an animal (e.g. a human patient); (ii) detecting the level of CYP24 within the biological sample; and (iii) comparing the level of CYP24 with a level of CYP24 in a control sample taken from a normal, cancer-free tissue where an increased level of CYP24 in the biological sample compared to the level of CYP24 in the control sample indicates the presence of said cancer in said animal.
Inventors:
Albertson, Donna, Gee.
Pinkel, Daniel
Collins, Choline
Gray, Joe, W.
Istria, Bourke
Pinkel, Daniel
Collins, Choline
Gray, Joe, W.
Istria, Bourke
Application Number:
JP2000609598A
Publication Date:
October 12, 2011
Filing Date:
March 06, 2000
Export Citation:
Assignee:
The Regents of The University of California
International Classes:
C12Q1/68; G01N33/50; A61K31/00; A61K31/59; A61K31/7105; A61K31/711; A61K38/00; A61K45/00; A61K48/00; A61P35/00; A61P35/04; C12N5/00; C12N5/06; C12N5/08; C12N9/00; C12N15/09; C12Q1/00; C12Q1/02; C12Q1/24; C12Q1/25; C12Q1/26; C12Q1/48; G01N1/00; G01N1/10; G01N31/00; G01N31/10; G01N33/15; G01N33/48; G01N33/483; G01N33/487; G01N33/49; G01N33/493; G01N33/53; G01N33/566; G01N33/573; G01N33/574; G01N33/82
Foreign References:
| WO1998002539A1 | 1998-01-22 |
Attorney, Agent or Firm:
Atsushi Nakajima
Kato Kazunori
Katsuichi Nishimoto
Kato Kazunori
Katsuichi Nishimoto