Title:
Screening based on the blood for detecting a neurological disease in primary care setting
Document Type and Number:
Japanese Patent JP6228302
Kind Code:
B2
Abstract:
The present invention includes methods and kits for the diagnosing a neurological disease within primary care settings comprising: obtaining a blood test sample from a subject, measuring IL-7 and TNFα biomarkers in the blood sample, comparing the level of the one or a combination of biomarkers and neurocognitive screening tests with the level of a corresponding one or combination of biomarkers in a normal blood sample and neurocognitive screening tests, and predicting that an increase in the level of the blood test sample in relation to that of the normal blood sample indicates that the subject is likely to have a neurological disease.
Inventors:
Obryant Sid E.
Barber Robert Sea.
Xiao Guanhua
German Dwight
Barber Robert Sea.
Xiao Guanhua
German Dwight
Application Number:
JP2016525462A
Publication Date:
November 08, 2017
Filing Date:
July 09, 2014
Export Citation:
Assignee:
UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH
International Classes:
G01N33/68; C12Q1/68; G01N33/53; G01N33/532; G01N33/533; G01N33/534; G01N33/542; G16B20/20; G16B20/40; G16B25/10
Domestic Patent References:
| JP2008506415A | ||||
| JP2013511506A | ||||
| JP2008544225A |
Foreign References:
| WO2011143597A1 | ||||
| WO2007094472A1 | ||||
| US20150241454 |
Other References:
Sid E,A Blood-Based Algorithm for the Detection of Alzheimer's Disease,Dement Geriatr Cogn Disord,2011年 9月,Vol.32 No.1,Page.55-62,Published online 2011 Aug 24
O'Bryant SE,A blood-based screening tool for Alzheimer's disease that spans serum and plasma: findings from TARC and ADNI,PLoS One,2011年,Vol.6 No.12,Page.e28092
Doecke James D,Blood-based protein biomarkers for diagnosis of Alzheimer disease,Archives of neurology,2012年10月,Vol. 69 No. 10,Page. 1318-1325
O'Bryant SE,A blood-based screening tool for Alzheimer's disease that spans serum and plasma: findings from TARC and ADNI,PLoS One,2011年,Vol.6 No.12,Page.e28092
Doecke James D,Blood-based protein biomarkers for diagnosis of Alzheimer disease,Archives of neurology,2012年10月,Vol. 69 No. 10,Page. 1318-1325
Attorney, Agent or Firm:
Masaki Hirota
Seiji Ozawa
Yusaku Tokai
Kazuhiro Matsuda
Makoto Horiuchi
Masako Yamauchi
Shuichi Sonomoto
Akihiro Yamamura
Seiji Ozawa
Yusaku Tokai
Kazuhiro Matsuda
Makoto Horiuchi
Masako Yamauchi
Shuichi Sonomoto
Akihiro Yamamura