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Title:
SEMISYNTHETIC ANALOG IMMUNOMODULATOR OF RAPAMYCIN (MACROLIDE)
Document Type and Number:
Japanese Patent JP2008156369
Kind Code:
A
Abstract:

To provide semisynthetic analogs of rapamycin as a therapeutic agent of immunomodulatory disorders.

Compounds such as semisynthetic analogs of rapamycin and pharmaceutically permissible salts, esters, amides, prodrugs and the like thereof are produced as a starting compound, which rapamycin is one of macrolide compounds obtained by fermentation and is a macrocyclic trien compound produced by Streptomyces hygroscopicus. Production of the intermediate useful for the methods, and use of the pharmaceutical compositions of the active ingredients and for treating immunomodulatory disorders, are provided.


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Inventors:
OR YAT SUN
LULY JAY R
WAGNER ROLF
Application Number:
JP2008025068A
Publication Date:
July 10, 2008
Filing Date:
February 05, 2008
Export Citation:
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Assignee:
ABBOTT LAB
International Classes:
C07D498/18; A61K31/436; A61P37/02; A61P37/06
Domestic Patent References:
JP4105761B22008-06-25
JPH06211870A1994-08-02
JPH05148271A1993-06-15
JPH05112573A1993-05-07
JPH0578377A1993-03-30
JPH04230687A1992-08-19
JPS62215592A1987-09-22
Foreign References:
WO1994009010A11994-04-28
US5233036A1993-08-03
WO1993011130A11993-06-10
WO1992005179A11992-04-02
WO1992021341A11992-12-10
US5258389A1993-11-02
US5260300A1993-11-09
US5262423A1993-11-16
US5151413A1992-09-29
US5100883A1992-03-31
WO1993018043A11993-09-16
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura



 
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