Title:
短い共役オリゴ電解質及びその使用
Document Type and Number:
Japanese Patent JP7362131
Kind Code:
B2
Abstract:
Compositions and methods of making and using thereof are provided with a specific antimicrobial activity and efficacy toward Gram-positive and Gram-negative bacteria and low levels of toxicity toward mammalian cells. The compositions include water-soluble molecules characterized by a hydrophobic interior fragment and side groups containing cationic groups. A class of these molecules is provided with variations in the length of the internal conjugated segment and in other molecular features, which impact the efficacy and toxicity. The substituents on the cationic functional group, the structural variations on the solubilizing group, and the length of the conjugated segment are important features affecting the antimicrobial property and the non-toxicity to mammalian cells of the composition.
Inventors:
Bazan, Guillermo
Tsang, Zichao
Moreland, Alex
Mahan, Michael Jay.
Heisoff, Douglas M.
Limwon Yut, Jackalin
D, Chen Yao
Tsang, Zichao
Moreland, Alex
Mahan, Michael Jay.
Heisoff, Douglas M.
Limwon Yut, Jackalin
D, Chen Yao
Application Number:
JP2020551278A
Publication Date:
October 17, 2023
Filing Date:
March 21, 2019
Export Citation:
Assignee:
The Regents of the University of California
International Classes:
C07C217/18; C07C279/08; C07C309/14; C07D211/06; C07D213/04
Domestic Patent References:
| JP56008350A | ||||
| JP55143940A |
Foreign References:
| US20040192968 | ||||
| WO2006015959A1 |
Other References:
Chem. Sci.,2016年,Vol.7,pp.5714-5722
Adv. Mater.,2013年,Vol.25,pp.1593-1597
Biochemistry,2015年,Vol.106,pp.379-382
Chem. Comm.,2014年,Vol.50,pp.14859-14861
JOURNAL OF MATERIAL CHEMISTRY,2012年,Vol.22, No.5,pp.1977-1984
Chem. Sci.,2016年,Vol.7,pp.5224-5229
Chem. Mater.,2014年,Vol.26,pp.4612-4619
Macromolecules,2016年,Vol.49,pp.2526-2532
Adv. Mater.,2013年,Vol.25,pp.1593-1597
Biochemistry,2015年,Vol.106,pp.379-382
Chem. Comm.,2014年,Vol.50,pp.14859-14861
JOURNAL OF MATERIAL CHEMISTRY,2012年,Vol.22, No.5,pp.1977-1984
Chem. Sci.,2016年,Vol.7,pp.5224-5229
Chem. Mater.,2014年,Vol.26,pp.4612-4619
Macromolecules,2016年,Vol.49,pp.2526-2532
Attorney, Agent or Firm:
Hiroshi Kobayashi
Norio Omori
Kyoei Sugiyama
Yasuhito Suzuki
Norio Omori
Kyoei Sugiyama
Yasuhito Suzuki
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