Title:
SIALIC ACID DERIVATIVE AND ITS PREPARATION
Document Type and Number:
Japanese Patent JPS60190791
Kind Code:
A
Abstract:
NEW MATERIAL:An N-acetylneuraminic acid derivative shown by the formula I (R1 is H, or acetyl; R2 is nucleotide residue; R3 is carboxyl, or methoxycarbonyl).
EXAMPLE: 2',3'-Isopropylidene-5'-O-(4-N-acetyl-2,4-dideoxy-1-carboxyl-D-glycero- β-D-galacto-octapyranosyl)uridine.
USE: An inhibitor against metastasis of cancer.
PREPARATION: Methyl-2-chloro-4,7,8,9-tetra-O-acecyl- β -D-N-acetylneuraminate shown by the formula II is reacted with a compound shown by the formula R2- H in a molar ratio of preferably 1.2:1 in the presence of a catalyst (preferably mercuric bromide). The reaction product is optionally hydrolyzed, it is isolated by rechromatography method, and purified.
Inventors:
OGURA HARUO
FURUHATA KIMIO
OOSAWA TOSHIAKI
TOYOSHIMA SATOSHI
SHIDORI YOSHIYASU
ITOU MASAYOSHI
YOSHIMURA SHIYOUJI
FURUHATA KIMIO
OOSAWA TOSHIAKI
TOYOSHIMA SATOSHI
SHIDORI YOSHIYASU
ITOU MASAYOSHI
YOSHIMURA SHIYOUJI
Application Number:
JP4490684A
Publication Date:
September 28, 1985
Filing Date:
March 09, 1984
Export Citation:
Assignee:
KANTO ISHI PHARMA CO LTD
International Classes:
A61K31/70; A61K31/7042; A61K31/7052; A61K31/7064; A61K31/7072; A61K31/7076; A61P35/00; C07H19/04; C07H19/06; C07H19/067; C07H19/16; C07H19/167; (IPC1-7): A61K31/70; C07H19/06; C07H19/16
Attorney, Agent or Firm:
Minoru Nakamura