Title:
ヘモフィルス属インフルエンザ菌ｂ型に対するワクチンとしての安定した加水分解耐性合成ポリリボシルリビトールホスフェート誘導体
Document Type and Number:
Japanese Patent JP6784841
Kind Code:
B2
Abstract:
The present invention provides a stable synthetic saccharide of Hib polyribosylribitol-phosphate (PRP) derivative and conjugate thereof. Said saccharide, said conjugate and pharmaceutical compositions thereof are hydrolysis-resistant, long-term stable and useful for the prevention and/or treatment of diseases associated with Haemophilus influenzae, and more specifically of diseases associated with Haemophilus influenzae type b, preferably diseases selected from meningitis, pneumonia, and epiglotitis. They have general formula (I): wherein A is formula (II) or formula (III); B is formula (IV); C is formula (V); D is formula (VI); E is formula (VII); F is formula (VIII) or formula (IX).
Inventors:
Seeberger Peter Her.
Pereira Crannie Rebeb
Pereira Crannie Rebeb
Application Number:
JP2019526376A
Publication Date:
November 11, 2020
Filing Date:
July 28, 2017
Export Citation:
Assignee:
Max Plank Gesell Shaft Tour Federundel Wissenshakhten A Four
International Classes:
C07H15/04; A61K31/7004; A61K39/102; A61K39/39; A61P1/02; A61P11/00; A61P25/00; A61P31/04; A61P37/04
Foreign References:
| WO2016044164A1 |
Other References:
VEREZ-BENCOMO,V.,SCIENCE,2004年 7月23日,305,522-525
GILL DAVINDER, HARALE KISHORE, ET AL,SYNTHESIS OF HAEMOPHILUS INFLUENZAE TYPE B (HIB) SACCHARIDES,インド特許公報,IN,2015年 4月10日,IN 2989DE2013 A
FRASER B A,MASS-SPECTRAL STUDIES OF ISOMETRIC D-RIBOFURANOSYLRIBITOL DISACCHARIDES FROM THE CAPSULAR 以下備考,CARBOHYDRATE RESEARCH,英国,PERGAMON,1979年 8月,VOL:73, NR:1,PAGE(S):59 - 65,POLYSACCHARIDES OF HAEMOPHILUS INFLUENZAE TYPE B AND ESCHERICHIA COLI K 100,URL,http://dx.doi.org/10.1016/S0008-6215(00)85474-9
GILL DAVINDER, HARALE KISHORE, ET AL,SYNTHESIS OF HAEMOPHILUS INFLUENZAE TYPE B (HIB) SACCHARIDES,インド特許公報,IN,2015年 4月10日,IN 2989DE2013 A
FRASER B A,MASS-SPECTRAL STUDIES OF ISOMETRIC D-RIBOFURANOSYLRIBITOL DISACCHARIDES FROM THE CAPSULAR 以下備考,CARBOHYDRATE RESEARCH,英国,PERGAMON,1979年 8月,VOL:73, NR:1,PAGE(S):59 - 65,POLYSACCHARIDES OF HAEMOPHILUS INFLUENZAE TYPE B AND ESCHERICHIA COLI K 100,URL,http://dx.doi.org/10.1016/S0008-6215(00)85474-9
Attorney, Agent or Firm:
Nagoya International Patent Service Corporation