Title:
STABLY-TRANSFORMED MAMMALIAN CELLS EXPRESSING REGULATED, INFLAMMATORY CYCLOOXYGENASE
Document Type and Number:
Japanese Patent JP2004105186
Kind Code:
A
Abstract:
To provide a method for examination of efficacy of conventional anti-inflammatory agents in molecular level, and to improve method for evaluating efficacy of latent anti-inflammatory agents and to provide reagents used in the methods.
The transgenic mammalian cell line is provided which contains chromosomally integrated, recombinant DNA. The DNA expresses mammalian glucocorticoid-regulated inflammatory prostaglandin G/H synthase (griPGHS). The DNA does not express constitutive PGHS. The cell line does not express endogenous PGHS activity.
Inventors:
YOUNG DONALD A
O'BANION MICHAEL K
WINN VIRGINIA D
O'BANION MICHAEL K
WINN VIRGINIA D
Application Number:
JP2003331571A
Publication Date:
April 08, 2004
Filing Date:
September 24, 2003
Export Citation:
Assignee:
UNIV ROCHESTER
International Classes:
A61K45/00; A61P29/00; A61P43/00; C12N5/00; C12N5/10; C12N9/02; C12N9/99; C12N15/53; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; C12N15/09; G01N33/53; G01N33/566; G01N33/68; G01N33/88; C12R1/91; (IPC1-7): C12N15/09; A61K45/00; A61P29/00; A61P43/00; C12N5/10; C12N9/02; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N33/566
Attorney, Agent or Firm:
Kunihiko Ohashi
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