Title:
SUBSTITUTED ETHENYL DERIVATIVE OF 1H-PYRAZOLO(1,5-A)PYRIMIDINE
Document Type and Number:
Japanese Patent JPS58172391
Kind Code:
A
Abstract:
Compounds of the formula (I) (I) wherein R1 is: (a) hydrogen, or C1-C6 alkyl; (b) an unsubstituted 2-pyridyl or 3-pyridyl group; (c) a benzyl group, wherein the phenyl ring is unsubstituted or substituted by halogen, C1-C6 alkoxy or C1-C6 alkyl; (d) a phenyl ring, unsubstituted or substituted by one or two groups chosen from halogen, trihalomethyl, C1-C6 alkoxy, C1-C6 alkyl, C2-C6 alkanoylamino, nitro and amino; each of R2 and R3 independently represents hydrogen, halogen or C1-C6 alkyl; R4 represents a 2-pyridyl, 3-pyridyl or 4-pyridyl group, unsubstituted or substituted by C1-C6 alkyl; and the pharmaceutically acceptable salts thereof are disclosed. The compounds have activity in the gastroenteric system, particularly anti-ulcerogenic and gastric anti-secretory activity. Additionally, the compounds have activity in reducing the undesired gastrointestinal side-effects resulting from systemic administration of anti-inflammatory prostaglandin synthetase inhibitors.
Inventors:
JIYANFUEDERIKO DORIA
KARURO PATSUSAROTSUTEI
JIYURIAANA ARUKAARI
KARURO PATSUSAROTSUTEI
JIYURIAANA ARUKAARI
Application Number:
JP4802283A
Publication Date:
October 11, 1983
Filing Date:
March 24, 1983
Export Citation:
Assignee:
ERBA CARLO SPA
International Classes:
A61K31/505; A61K31/519; A61P1/04; C07D487/04; (IPC1-7): A61K31/505; C07D487/04
Attorney, Agent or Firm:
Chika Takagi