Title:
置換された三環式化合物
Document Type and Number:
Japanese Patent JP4435330
Kind Code:
B2
Abstract:
A class of novel tricyclics is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
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Inventors:
Benjamin Alan Anderson
Nicholas James Back
Jolly Ann Bastian
Nancy Kay Hahn
Richard Waltz Harper
Gary Alan Height
Michael Dean Kinnick
Horchen Lin
Richard James Roncharich
John McNeill McGill The Third
Edward David Michelich
John Michael Morin Jr.
Michael Leroy Phillips
Michael Enrico Richett
Daniel John Sal
Jason Scott Sawyer
Richard Walter Shevitz
Robert Theodore Basilev
Nicholas James Back
Jolly Ann Bastian
Nancy Kay Hahn
Richard Waltz Harper
Gary Alan Height
Michael Dean Kinnick
Horchen Lin
Richard James Roncharich
John McNeill McGill The Third
Edward David Michelich
John Michael Morin Jr.
Michael Leroy Phillips
Michael Enrico Richett
Daniel John Sal
Jason Scott Sawyer
Richard Walter Shevitz
Robert Theodore Basilev
Application Number:
JP15240099A
Publication Date:
March 17, 2010
Filing Date:
April 16, 1999
Export Citation:
Assignee:
Shionogi Pharmaceutical Co., Ltd.
International Classes:
C07D209/88; A61K31/00; C07D401/06; A61K31/40; A61K31/403; A61K31/44; A61K31/4427; A61K31/443; A61K31/4433; A61K31/4439; A61P1/00; A61P7/00; A61P11/00; A61P11/06; A61P19/00; A61P19/02; A61P29/00; A61P31/00; A61P31/04; A61P35/00; A61P43/00; C07C205/59; C07C229/48; C07C229/60; C07D209/82; C07D209/86; C07D405/04; C07D409/04
Domestic Patent References:
| JP2001503055A | ||||
| JP11322713A | ||||
| JP5502222A | ||||
| JP7010838A | ||||
| JP7025850A |
Foreign References:
| US3579534 | ||||
| EP0779271A1 |
Other References:
HALL,D.M. et al.,Some racemization data for compounds owing their optical activity to restricted rotation,Journal of the Chemical Society,1960年,p.490-494
HANFORD,W.E. et al.,Stereochemistry of biphenyls. XLI. The effect of 4'-substitution on the rate of racemization of 2-nitro-6-carboxy-2' methoxybiphenyl,Journal of the American Chemical Society,1935年,Vol.57,p.1592-1595
VANARENDONK,A.M. et al.,Stereochemistry of biphenyls. XXXIII. Preparation and properties of 2,3'-dinitro-6-carboxy-2',6'-dimethoxybiphenyl and 2-nitro-6-carboxy-2'-fluoro-6'-methoxybiphenyl,Journal of the American Chemical Society,1933年,Vol.55,p.4230-4234
HANFORD,W.E. et al.,Stereochemistry of biphenyls. XLI. The effect of 4'-substitution on the rate of racemization of 2-nitro-6-carboxy-2' methoxybiphenyl,Journal of the American Chemical Society,1935年,Vol.57,p.1592-1595
VANARENDONK,A.M. et al.,Stereochemistry of biphenyls. XXXIII. Preparation and properties of 2,3'-dinitro-6-carboxy-2',6'-dimethoxybiphenyl and 2-nitro-6-carboxy-2'-fluoro-6'-methoxybiphenyl,Journal of the American Chemical Society,1933年,Vol.55,p.4230-4234
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Yushiro Tsuboi
Nagatoshi Shinagawa
Samejima Mutsumi
Yushiro Tsuboi
Nagatoshi Shinagawa