PURPOSE: To provide the titled novel derivative which is a specific sulfated β-glycolipid derivative and useful as a selectin-mediated cellular adhesion inhibitor or the like effective for the treatment, prevention and the like of inflammatory diseases, mediated by the binding of a selectin observed in intercellular adhesion, and other symptoms.
CONSTITUTION: There is provided a novel sulfated β-glycolipid derivative useful as a selectin-mediated cellular adhesion inhibitor effective for the treatment, prevention and the like of inflammatory diseases, mediated by the binding of a selectin observed in intercellular adhesion, and other pathological symptoms, represented by formula I [wherein R is an acyl residue of a fatty acid; R1 is a radical of formula II (wherein m is 0 or 1; and n is an integer of 5-14); R2 to R6 are each the formula: SO3H, (substituted) alkanoyl, arylalkyl and arylcarbonyl; provided that at least two of R2 to R6 are the formula: SO3H; or R4 and R6 join together to form benzylidene; or R3 and R4 join together to form isopropylidene]. This compound is obtained by condensation of a compound of formula III (wherein Ac is acetyl) with an azide alcohol of formula IV (wherein Bz is benzyl), followed by reduction, acylation, sulfation and hydrolysis.
ARAIN MAATERU
AREJIYANDORO EI ARUFUO
