To provide a compound which has excellent selectivity and a strong β3 adrenalin receptor-stimulating action and is useful as an agent for preventing and treating obesity, diabetes, hyperlipemia, hypersensitive colon syndrome, acute or chronic diarrhea, pollakiuria, anischuria, urolithiasis and the like.
This sulfonyloxyindole derivative represented by the general formula [I] (R1 is H or the like; R3 and R4 are each H, a lower alkyl, or the like; R5 is H, a lower alkyl, or the like; R6 is a lower alkyl; R7 is H or the like; R2 is X1-R8, OSO2-R9 or X2-A1-R10 or the like; X1 is O, S or NH; R8 is a lower alkyl, or the like; R9 is phenyl, naphthyl, a heteroaryl, or the like; X2 is O, S, NH or SO2; A1 is a lower alkylene moiety or the like; R10 is phenyl, naphthyl or a heteroaryl) or its physiologically acceptable salt.
MIZUNO KAZUHIRO
SAWA MASAAKI
KATO SHIROU
TATEISHI HIROTAKA
OUE MAYUMI
TSUJIUCHI HIROSHI
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