Title:
徐放性水性エマルション
Document Type and Number:
Japanese Patent JP3583435
Kind Code:
B2
Abstract:
A controlled release aqueous emulsion is disclosed, as are its method of manufacture and use as a vehicle for delivering medicaments in liquid form. A contemplated emulsion comprises an oil-in-water emulsion having an average oil particle size of about 100 nm to about 250 nm, a pH value of about 4.5 to about 8.0 and a viscosity at 20 DEG -25 DEG C. of 1 to about 1000 cps. The water phase constitutes at least 25 weight percent of the total composition. The oil phase is a wax matrix that is a wax having a melting point of about 40 DEG to about 80 DEG C. and is present in an amount of about 3 to about 30 percent of the total composition. A pharmaceutically effective amount of a pharmacologically active compound that is free from decomposition at a temperature below about 90 DEG C. is dissolved or dispersed in the wax matrix. The oil and water phases are emulsified by an emulsifying agent that provides freedom from phase separation at a pH value of about 4.5 to about 8, while also providing phase separation at a pH value below about 2.0. The emulsifier, based on lecithin, is present at about 2 to about 20 weight percent of the total composition. The composition can also contain zero to about 35 weight percent additional excipient.
Inventors:
Tabby BS Emile
Mendes Robert W
Patak Knitting Pee
Mendes Robert W
Patak Knitting Pee
Application Number:
JP50259396A
Publication Date:
November 04, 2004
Filing Date:
June 21, 1995
Export Citation:
Assignee:
Ascent Pediatrics Incorporated
International Classes:
A61K9/00; A61K9/107; A61K9/51; A61K31/192; A61K31/505; A61K47/10; A61K9/14; A61K47/24; (IPC1-7): A61K9/14; A61K9/107; A61K31/192; A61K31/505; A61K47/10; A61K47/24
Foreign References:
| WO1994026252A1 |
Attorney, Agent or Firm:
Minoru Nakamura
Fumiaki Otsuka
Shishido Kaichi
Hideto Takeuchi
Toshio Imajo
Nobuo Ogawa
Village shrine Atsuo
Fumiaki Otsuka
Shishido Kaichi
Hideto Takeuchi
Toshio Imajo
Nobuo Ogawa
Village shrine Atsuo