SUSTAINED-RELEASING SHEET FOR EVAPORATIVE DRUG AND METHOD OF MAKING THE SAME

Japanese Patent JP3733405

B2

PURPOSE: To provide a sustained-releasing sheet preparation having the controlled delivering faculty of the desired concentration of drug at application, wherein a sheet has the laminated structure comprising a film substrate for the drug barrier, an adhesive layer in which an evaporative drug being reserved in the elevated concentration, a control film for the sustained-release of the drug ingredients, and a protecting film for the drug barrier which prevents the release of ingredients before use.
CONSTITUTION: A matrix layer (5) of adhesive extended with an evaporative drug is laminated on a base film (4) having the barrier function of drug. A release-controlling film (2) and then a strippable protecting film (1) having the barrier function of the drug migration are laminated on an adhesive layer (5). As a layer (5) is laminated between the barrier layers (4) and (1), the drug is protected from releasing out of a sheet device and can be reserved at a high content in an adhesive layer without thermal decomposition and evaporative dissipation before use. In application, a protecting foil (1) for the drug barrier is peeled off, and the drug ingredients can be delivered through a release-control film at the desired concentration.

Kazuya Kato

JP19198293A

January 11, 2006

July 06, 1993

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Mitsubishi Chemical Foods Co., Ltd.
LINTEC CORPORATION

A61K8/18; A61L9/12; A61K8/00; A61Q13/00; B32B7/02; C08K3/22; C08K5/00; (IPC1-7): A61L9/12; A61K7/46; B32B7/02; C08K5/00

JP58179138U
JP3053247U
JP61010747U
JP62073931U
JP1212558A
JP63309270A
JP58179138U
JP3053247U
JP61010747U

Yoshihiro Shimizu
Shinichi Abe
Yuji Tsujida

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