Title:
標的遺伝子治療のための合成コンビナトリアルＡＡＶカプシドライブラリー
Document Type and Number:
Japanese Patent JP7007337
Kind Code:
B2
Abstract:
Disclosed are compositions and methods for producing modified adeno-associated virus (AAV) cap genes and combinatorial libraries of chimeric AAV vectors and virions; selecting for virions displaying cell-specific tropisms; and, in certain embodiments, producing helper vectors containing one or more modified AAV cap genes. The synthetic combinatorial AAV capsid libraries of the invention are useful in introducing into selected target host cells one or more nucleic acid molecules. The viral vectors and genetic constructs disclosed herein are also useful in a variety of diagnostic and/or therapeutic gene-therapy regimens.
Inventors:
Marsik, Damien
Zorotkin, Sergey
Agbanje-McKenna, Mavis
Zorotkin, Sergey
Agbanje-McKenna, Mavis
Application Number:
JP2019137247A
Publication Date:
January 24, 2022
Filing Date:
July 25, 2019
Export Citation:
Assignee:
University of Florida Research Foundation Incorporated
International Classes:
A61K48/00; A61P43/00; C07K14/015; C12N7/01; C12N15/864
Other References:
J. Virol., 2006, Vol.80, No.2, p.821-834
Mol. Ther., 2012, Vol.20, No.2, p.443-455
J. Virol., 2003, Vol.77, No.12, p.6995-7006
Proc. Natl. Acad. Sci., 2008, Vol.105, No.22, p.7827-7832
ウイルス, 2007, Vol.57, No.1, p.47-56
Mol. Ther., 2012, Vol.20, No.2, p.443-455
J. Virol., 2003, Vol.77, No.12, p.6995-7006
Proc. Natl. Acad. Sci., 2008, Vol.105, No.22, p.7827-7832
ウイルス, 2007, Vol.57, No.1, p.47-56
Attorney, Agent or Firm:
Yoshiyuki Inaba
Toshifumi Onuki
Akihiko Eguchi
Kazuhiko Naito
Toshifumi Onuki
Akihiko Eguchi
Kazuhiko Naito
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