Title:
置換スルホキシドの合成法
Document Type and Number:
Japanese Patent JP3795917
Kind Code:
B2
Abstract:
PCT No. PCT/SE95/00818 Sec. 371 Date Jul. 14, 1995 Sec. 102(e) Date Jul. 14, 1995 PCT Filed Jul. 3, 1995 PCT Pub. No. WO96/02535 PCT Pub. Date Feb. 1, 1996A novel process for enantioselective synthesis of single enantiomers of omeprazole or its alkaline salts, of other optically pure substituted 2-(2-pyridinylmethyl-sulphinyl) -1H-benzimidazoles as well as of other structurally related sulphoxides or their alkaline salts. The claimed process is an asymmetric oxidation of a pro-chiral sulphide to the single enantiomers or an enantiomerically enriched form of the corresponding sulphoxide. The application also claims the enantiomeric sulphoxide products produced by the process and their use in medicine.
Inventors:
Larson, Erik Magnus
Sternhede, Urban Yarn
Henrik, Sierensen
Vuong Unge, Pell Auskar Sveerkel
Hannah Christina, Cotton
Sternhede, Urban Yarn
Henrik, Sierensen
Vuong Unge, Pell Auskar Sveerkel
Hannah Christina, Cotton
Application Number:
JP50493896A
Publication Date:
July 12, 2006
Filing Date:
July 03, 1995
Export Citation:
Assignee:
ASTRAZENECA AKTIEBOLAG
International Classes:
C07D235/28; A61K31/415; C07D401/12; A61K31/4184; A61P1/04; A61P43/00; B01J21/06; B01J31/22; C07B57/00; C07B61/00; C07D471/04
Domestic Patent References:
| JP5247035A | ||||
| JP2078665A | ||||
| JP64003157A |
Other References:
Kristine Sigrist-Nelson et al, Ro 18-5364, a potent new inhibitor of the gastric (H++K+)-ATPase, Eur. J. Biochem., 1987年,166, p.453-459
P. Pitchen et al. An Efficient Asymmetric Oxidation of Sulfides to Sulfoxides, J. Am. Chem. Soc., 1984年,106, p.8188-8193
S. H. Zhao et al, Asymmetric Oxidation of Sulfides Mediated by Chral Titanium Complexes : Mechanistic and Synthetic As, Tetrahedron, 1987年,43/21, p.5135-5144
Shin-ichi Yamada et al, Syntheses and Antiulcer Activities of Novel 2-[(6, 7, 8, 9-Tetrahydro-5H-Cyclohepta[b]Pyridin-9-yl)S, Chem. Pharm. Bull., 1994年,42/3, p.718-720
P. Pitchen et al. An Efficient Asymmetric Oxidation of Sulfides to Sulfoxides, J. Am. Chem. Soc., 1984年,106, p.8188-8193
S. H. Zhao et al, Asymmetric Oxidation of Sulfides Mediated by Chral Titanium Complexes : Mechanistic and Synthetic As, Tetrahedron, 1987年,43/21, p.5135-5144
Shin-ichi Yamada et al, Syntheses and Antiulcer Activities of Novel 2-[(6, 7, 8, 9-Tetrahydro-5H-Cyclohepta[b]Pyridin-9-yl)S, Chem. Pharm. Bull., 1994年,42/3, p.718-720
Attorney, Agent or Firm:
Chika Takagi
Tatsuo Sato
Kosuke Nishimura
Tatsuo Sato
Kosuke Nishimura