Title:
時間分解蛍光分光法のためのシステム、デバイス、および方法
Document Type and Number:
Japanese Patent JP7266519
Kind Code:
B2
Abstract:
Provided herein are devices, systems, and methods for characterizing a biological sample in vivo or ex vivo in real-time using time-resolved spectroscopy. A light source generates a light pulse or continuous light wave and excites the biological sample, inducing a responsive fluorescent signal. A demultiplexer splits the signal into spectral bands and a time delay is applied to the spectral bands so as to capture data with a detector from multiple spectral bands from a single excitation pulse. The biological sample is characterized by analyzing the fluorescence intensity magnitude and/or decay of the spectral bands. The sample may comprise one or more exogenous or endogenous fluorophore. The device may be a two-piece probe with a detachable, disposable distal end. The systems may combine fluorescence spectroscopy with other optical spectroscopy or imaging modalities. The light pulse may be focused at a single focal point or scanned or patterned across an area.
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Inventors:
Butte, Pyramod
black, keith
Kavanaugh, Jack
Boltnik, Bartosz
Nie, Zhaojun
black, keith
Kavanaugh, Jack
Boltnik, Bartosz
Nie, Zhaojun
Application Number:
JP2019502534A
Publication Date:
April 28, 2023
Filing Date:
March 31, 2017
Export Citation:
Assignee:
Black Light Surgical, Inc.
Cedars-Sinai Medical Center
Cedars-Sinai Medical Center
International Classes:
G01N21/64; A61B10/00; A61B17/32; A61B18/02; A61B18/14; A61B18/22
Domestic Patent References:
| JP2011062348A | ||||
| JP7222712A | ||||
| JP2013027392A | ||||
| JP2011196852A | ||||
| JP9503866A |
Foreign References:
| US20020016533 | ||||
| US20100069720 | ||||
| US5749830 | ||||
| US20040029213 | ||||
| WO2001094528A2 |
Attorney, Agent or Firm:
Shusaku Yamamoto
Morishita Natsuki
Morishita Natsuki
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