TRANSGENIC MAMMAL HAVING HUMAN Ig GENE LOCI INCLUDING PLURALITY OF VH AND Vκ REGIONS AND ANTIBODY PRODUCED THEREFROM

Title:

TRANSGENIC MAMMAL HAVING HUMAN Ig GENE LOCI INCLUDING PLURALITY OF VH AND Vκ REGIONS AND ANTIBODY PRODUCED THEREFROM

Document Type and Number:

Japanese Patent JP2011212019

Kind Code:

A

Abstract:

To provide a transgenic animal for humanized monoclonal antibody production and a humanized monoclonal antibody.

There is provided a transgenic non-human animals that are engineered to contain human immunoglobulin gene loci. In particular, the animals possess human Ig gene loci that include a plurality of variable (VH and Vκ) gene regions. The inclusion of a plurality of variable region genes enhances the specificity and diversity of human antibodies produced by the animal. Further, the inclusion of such regions enhances and reconstitutes B-cell development to the animals, such that the animals possess abundant mature B-cells secreting extremely high-affinity antibodies.

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Inventors:

JAKOBOVITS AYA
KUCHERLAPATI RAJU
KLAPHOLZ SUE
MENDEZ MICHAEL
GREEN LARRY

Application Number:

JP2011146571A

Publication Date:

October 27, 2011

Filing Date:

June 30, 2011

Export Citation:

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Assignee:

AMGEN FREMONT INC

International Classes:

A01K67/027; C12N15/09; C07K14/415; C07K16/00; C07K16/18; C07K16/24; C07K16/28; C12N5/08; C12N15/85; C12P21/08; A61K39/00

Attorney, Agent or Firm:

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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