Title:
錠剤賦形剤
Document Type and Number:
Japanese Patent JP5101804
Kind Code:
B2
Abstract:
This invention relates to a composition comprising physically modified, partially pregelatinized starch, which is useful as a multi-functional excipient for solid dosage forms, a method of making such composition, and solid dosage forms prepared using the composition. Such composition is characterized by a predominance of particles having both birefringent and non-birefringent portions, a sedimentation volume of between 1.5 and 9 ml/g, and a cold water solubility of between 1 and 8 %. This free-flowing starch may have an average particle size greater than 30 µm, and a moisture content of between 5 and 12% by weight. The 500 mg placebo tablet prepared from such composition at 13 kN using a manual tablet press equipped with a 1.11cm (7/16") standard concave punches has a crushing strength of at least 160 Newtons, and a disintegration time of no more than 10 minutes.
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Inventors:
Yerizan
Chao Dong Xiao
Wolfgang Vinzas
Vincent green
Chao Dong Xiao
Wolfgang Vinzas
Vincent green
Application Number:
JP2005200496A
Publication Date:
December 19, 2012
Filing Date:
July 08, 2005
Export Citation:
Assignee:
Brnopu Twede Besloten Fennaught Shap
International Classes:
A61K47/36; A61K9/20; G09F9/00; H01L27/32; H01L51/52; H05B33/02; H05B33/12; H05B44/00
Domestic Patent References:
| JP4318001A | ||||
| JP11269202A |
Foreign References:
| US4072535 |
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Tetsuji Koga
Kenichi Kato
Nagasaka Tomoyasu
Yoshihiro Kobayashi
Takashi Ishida
Tetsuji Koga
Kenichi Kato
Nagasaka Tomoyasu
Yoshihiro Kobayashi