Title:
疾患、悪性病変、および障害の処置のための標的化された分裂生体分子コンジュゲート、ならびにそれらの生成方法
Document Type and Number:
Japanese Patent JP2010509194
Kind Code:
A
Abstract:
The present invention is directed to compositions and methods for the production of split-biomolecular conjugates for the directed targeting of nucleic acids and polypeptides. More preferably, the compositions and methods allow for the use of the split biomolecular conjugates for the treatment of diseases, malignancies, disorders and screening. In some embodiments, the split biomolecular conjugates comprise split effector protein fragments conjugated to a probe, and interaction of both probes with a target nucleic acid or target polypeptide, such as a pathogenic nucleic acid sequence or pathogenic protein, brings a the split-effector fragments together to facilitate the reassembly of the effector molecule. Depending on the effector molecule, the protein complementation results in a cellular effect, in particular for the treatment of diseases, malignancies and disorders.
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Inventors:
Demidoff Badim
Brude natalia
Canter charles
Evans william
Brude natalia
Canter charles
Evans william
Application Number:
JP2009534889A
Publication Date:
March 25, 2010
Filing Date:
October 26, 2007
Export Citation:
Assignee:
TRUSTEES OF BOSTON UNIVERSITY
St Jude Children's Research Hospital
St Jude Children's Research Hospital
International Classes:
A61K47/48; A61P25/16; A61P31/10; A61P31/12; A61P35/00; A61P37/00; C12Q1/26; C12Q1/34; C12Q1/68; C07K14/195; C07K14/415; C07K14/52; C07K19/00; C12N9/16; C12N9/22; C12N15/09
Domestic Patent References:
| JP2005538049A | 2005-12-15 | |||
| JP2009517408A | 2009-04-30 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Kazuya Kawamoto