Title:
テクネチウム-99m及びレニウムで標識した小型作用剤及び組織、臓器及び腫瘍の画像化方法
Document Type and Number:
Japanese Patent JP4796301
Kind Code:
B2
Abstract:
The present invention relates to compounds and related technetium and rhenium complexes thereof which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors. In another embodiment, the invention relates the methods of imaging tissues, organs or tumors using radiolabeled metal complexes, particularly tissues, organs, or tumors which express certain receptors to which the compounds or complexes of the invention have an affinity. The present invention also relates to methods of treating cancer, particularly those cancer lines which express certain receptors to which the compounds or complexes of the invention have an affinity. In yet another embodiment, the present invention provides methods of imaging and/or inhibiting receptors or neuroreceptors using compounds or complexes of the invention which have an affinity for the receptor or neuroreceptor to be imaged and/or inhibited.
Inventors:
Ashfaq Mohamed
Chun Chung
Alan Gee Jones
Alan Devison
Chun Chung
Alan Gee Jones
Alan Devison
Application Number:
JP2004551909A
Publication Date:
October 19, 2011
Filing Date:
November 08, 2003
Export Citation:
Assignee:
President and Fellows of Harvard College
International Classes:
C07C323/41; A61K31/555; A61K49/04; A61K51/00; A61P35/00; A61P43/00; C07C323/25; C07D211/14; C07D211/22; C07D211/52; C07D211/56; C07D211/58; C07F13/00
Domestic Patent References:
| JPH11514368A | 1999-12-07 | |||
| JPH11515029A | 1999-12-21 | |||
| JP2000319201A | 2000-11-21 | |||
| JPS615065A | 1986-01-10 |
Foreign References:
| WO2001083436A2 | 2001-11-08 | |||
| WO2001062301A2 | 2001-08-30 |
Attorney, Agent or Firm:
Norio Saeki