Title:
蛍光ナノ粒子を用いた、病理学的完全奏効（ｐＣＲ）の予測を支援するための検査支援方法
Document Type and Number:
Japanese Patent JP6922444
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide means (an inspection support method) for predicting if there will be pathological perfect response (pCR) if chemotherapy before operation using anticancer agents is carried out by using a sample (tissue slice of breast cancer) collected from a breast cancer patient to whom the chemotherapy before operation using anticancer agents is carried out.SOLUTION: An inspection support method includes the steps of: [1] obtaining a fluorescent image of a breast cancer tissue slice displaying luminescent spots of fluorescent nanoparticles labelling one or more types of breast cancer related protein; [2] obtaining one or more types of indexes related to an expression level of the breast cancer related protein on the basis of the luminescent spots of the fluorescent image; and [3] obtaining information for predicting pCR by analysis using the one or more types of indexes.SELECTED DRAWING: None
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Inventors:
Hideki Goda
Yu Takahashi
Kensaku Takanashi
Naohiro Okada
Yuichi Ozaki
Yoshihara Yuka
Ning Nakano
Kosuke Gonda
Noriaki Ouchi
Mika Watanabe
Hiroshi Tada
Minoru Miyashita
Shinzo Masuda
Towa Masakazu
Yu Takahashi
Kensaku Takanashi
Naohiro Okada
Yuichi Ozaki
Yoshihara Yuka
Ning Nakano
Kosuke Gonda
Noriaki Ouchi
Mika Watanabe
Hiroshi Tada
Minoru Miyashita
Shinzo Masuda
Towa Masakazu
Application Number:
JP2017111031A
Publication Date:
August 18, 2021
Filing Date:
June 05, 2017
Export Citation:
Assignee:
Konica Minolta Co., Ltd.
International Classes:
G01N33/48; G01N21/64; G01N33/483; G01N33/53; G01N33/68
Domestic Patent References:
| JP2011516407A | ||||
| JP2011227838A | ||||
| JP2006504937A | ||||
| JP2015525358A | ||||
| JP2014074724A | ||||
| JP2016508710A | ||||
| JP2012228233A |
Foreign References:
| WO2012035705A1 | ||||
| WO2015002082A1 | ||||
| WO2012029342A1 | ||||
| US20140162903 | ||||
| US20130178381 |
Other References:
YONEMORI, K. et al.,Immunohistochemical Expression of HER1, HER3 and HER4 in HER2-Positive Breast Cancer Patients Treated With Trastuzumab-Containing Neoadjuvant Chemotherapy,Journal of Surgical Oncology,2010年,101,222-227
ZHOU, L. et al.,Quantum Dot-based Immunohistochemistry for Pathological Applications,Cancer Translational Medicine,2016年,2(1),21-28
MIYASHITA, M. et al.,Quantitative diagnosis of HER2 protein expressing breast cancer by single-particle quantum dot imaging,Cancer Medicine,2016年,5(10),2813-2824
GONDA, K. et al.,Predictive diagnosis of the risk of breast cancer recurrence after surgery by single-particle quantum dot imaging,Scientific Reports,2015年,5,Article number:14322
ZHOU, L. et al.,Quantum Dot-based Immunohistochemistry for Pathological Applications,Cancer Translational Medicine,2016年,2(1),21-28
MIYASHITA, M. et al.,Quantitative diagnosis of HER2 protein expressing breast cancer by single-particle quantum dot imaging,Cancer Medicine,2016年,5(10),2813-2824
GONDA, K. et al.,Predictive diagnosis of the risk of breast cancer recurrence after surgery by single-particle quantum dot imaging,Scientific Reports,2015年,5,Article number:14322
Attorney, Agent or Firm:
Patent corporation ssinpat