Title:
テトラヒドロ-ナフタレンおよび尿素誘導体
Document Type and Number:
Japanese Patent JP2007509846
Kind Code:
A
Abstract:
This invention relates to tetrahydro-naphthalene and urea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The tetrahydro-naphthalene and urea derivatives of the present invention have vanilloid receptor (VR1) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urological diseases or disorders, such as detrusor overactivity (overactive bladder), urinary incontinence, neurogenic detrusor overactivity (detrusor hyperflexia), idiopathic detrusor overactivity (detrusor instability), benign prostatic hyperplasia, and lower urinary tract symptoms; chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, and inflammatory disorders such as asthma and chronic obstructive pulmonary (or airways) disease (COPD).
Inventors:
Axel Bowhon
Nicole Dietrichs
Ahim Hermann
Clemens Rustig
Heinrich Meyer
Joseph Pernerstorfer
Elke Rice Mueller
Moteto Mogi
Yura Tsuyoshi
Hiroshi Fujishima
Seki Masanori
Koriyama Yuji
Kayo Yasoshima
Keiko Misawa
Tajimi Masaomi
Yamamoto
Klaus Waberns
Fumihiko Hayashi
Yasuhiro Tsukimi
Jung Gupta
Nicole Dietrichs
Ahim Hermann
Clemens Rustig
Heinrich Meyer
Joseph Pernerstorfer
Elke Rice Mueller
Moteto Mogi
Yura Tsuyoshi
Hiroshi Fujishima
Seki Masanori
Koriyama Yuji
Kayo Yasoshima
Keiko Misawa
Tajimi Masaomi
Yamamoto
Klaus Waberns
Fumihiko Hayashi
Yasuhiro Tsukimi
Jung Gupta
Application Number:
JP2006534634A
Publication Date:
April 19, 2007
Filing Date:
October 02, 2004
Export Citation:
Assignee:
Bayer HealthCare AG
International Classes:
C07C275/32; A61K31/167; A61K31/17; A61K31/222; A61K31/357; A61K31/36; A61K31/405; A61K31/42; A61K31/433; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4412; A61K31/4418; A61K31/455; A61K31/4706; A61K31/472; A61K31/517; A61K47/48; A61P9/00; A61P9/10; A61P11/06; A61P13/00; A61P13/02; A61P13/08; A61P13/10; A61P19/02; A61P25/00; A61P29/00; A61P43/00; C07C233/29; C07C233/75; C07C235/16; C07C235/24; C07C235/38; C07C235/56; C07C235/64; C07C235/66; C07C237/04; C07C237/20; C07C275/30; C07C275/38; C07D209/18; C07D213/40; C07D213/53; C07D213/56; C07D213/61; C07D213/68; C07D213/81; C07D213/89; C07D215/46; C07D217/22; C07D239/94; C07D261/14; C07D285/06; C07D317/46; C07D317/66
Domestic Patent References:
| JP2006509018A | 2006-03-16 | |||
| JPH02175A | 1990-01-05 | |||
| JPH01313402A | 1989-12-18 | |||
| JPS58140054A | 1983-08-19 | |||
| JPS6434962A | 1989-02-06 | |||
| JP2003055209A | 2003-02-26 | |||
| JP2006509017A | 2006-03-16 | |||
| JP2005524717A | 2005-08-18 | |||
| JP2006517556A | 2006-07-27 |
Foreign References:
| WO2003049702A2 | 2003-06-19 | |||
| WO2003014064A1 | 2003-02-20 | |||
| WO2003070247A1 | 2003-08-28 | |||
| WO2003022809A2 | 2003-03-20 | |||
| WO2003055848A2 | 2003-07-10 | |||
| EP1493438A1 | 2005-01-05 | |||
| WO1998005651A1 | 1998-02-12 |
Attorney, Agent or Firm:
Aoyama Aoi
Mitsutaka Iwasaki
Yasuo Shibata
Mitsutaka Iwasaki
Yasuo Shibata