組換え欠陥ウイルスゲノムに基づくベクター及びワクチン製剤におけるそれらの使用

Title:

組換え欠陥ウイルスゲノムに基づくベクター及びワクチン製剤におけるそれらの使用

Document Type and Number:

Japanese Patent JP3769300

Kind Code:

B2

Abstract:

The vectors comprise a recombinant defective viral genome expressing at least one antigen suitable for the induction of systemic and secretory immune responses or an antibody conferring protection against an infectious agent. The defective viral genome comprises the genome of a parental virus having the viral replicase recognition signals located on ends 3' and 5', further comprising internal deletions, and wherein said defective viral genome depends on a helper virus for its replication and encapsidation. These vectors are suitable for the forming of a recombinant system comprising the aforesaid expression vector, and a helper virus. The system is suitable for the manufacture of mono- and polyvalent vaccines against infectious agents of different animal species, especially pigs, dogs and cats, and as expression vehicles for antibodies protective against infectious agents.

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Inventors:

Enjuanes Sanchez Lewis
Prana Duran Juan
Alonso Villa Nueva Sarah
Ballesteros Jillereno Em Luisa
Castilla Castrilon Joaquin
Gonzales Martinez Jose Manuel
Izeta Palmesan Andel
Mendes Tunznegui Ana
Muntion Saenz Maria
Penzes Zoltan
Sanchez Morgado Jose Manuel
Sanchez Sanchez Carlos Miguel
Smerdou Picasso Christian
Sora Grupegui Isabel

Application Number:

JP53230497A

Publication Date:

April 19, 2006

Filing Date:

March 12, 1997

Export Citation:

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Assignee:

Cyanamide Iberica S.A.

International Classes:

C12N15/09; A61K35/76; A61K39/12; A61K39/215; A61K39/225; A61K39/395; A61K48/00; A61P31/00; A61P31/12; A61P31/14; C07K14/17; C07K16/08; C07K16/10; C12N7/01; C12N15/50; C12N15/86; A61K39/00

Domestic Patent References:

JP5500607A

Other References:

Virology,Vol.208,No.1(1995)p.319-327
Adv.Exp.Med.Biol.,Vol.380(1995)p.583-589
J.Virol.,Vol.65,No.6(1991)p.3219-3226

Attorney, Agent or Firm:

Shotaro Mogami

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