治療剤

Japanese Patent JP5340729

B2

A compound of the formula (I): wherein R1, R2, R3, R4, Ar, A, n and m are defined herein, is disclosed as a GlyT1 inhibitor; pharmaceutical compositions containing the compound of the formula (I) are also disclosed as are their use in medicine, for example in the treatment of schizophrenia.

JP2002512998	[Title of the Invention] Adin used as a bactericidal / fungicide
WO/2002/028823	MALONAMID AND MALONAMIC ESTER DERIVATIVES WITH ANTITHROMBOTIC ACTIVITY, THEIR PREPARATION AND THEIR USE
WO/2000/071512	INHIBITORS OF FACTOR Xa

Bruckaby, Wesley Peter
Huscroft, Ian Thomas
Keown, Linda Elizabeth
Lewis, Richard Yard Thomas
Lavo, Pyotr Antoni
Street, leslie joseph
Christopher Giyogi, Thomson
Thomson, Joan

JP2008516399A

November 13, 2013

June 13, 2006

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Merck Sharp End Dome Limited

C07C317/32; A61K31/166; A61K31/337; A61K31/351; A61K31/40; A61K31/4192; A61K31/4196; A61K31/435; A61K31/44; A61K31/4406; A61K31/4433; A61K31/4439; A61K31/4453; A61K31/4458; A61K31/4465; A61K31/455; A61K31/4709; A61K31/5375; A61K31/5377; A61P25/18; C07D205/04; C07D207/08; C07D207/09; C07D207/12; C07D211/26; C07D211/70; C07D213/40; C07D213/82; C07D215/50; C07D221/22; C07D249/04; C07D249/12; C07D295/12; C07D309/04; C07D401/12; C07D405/12

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JP62158273A
JP64056672A
JP2007512251A
JP2008542348A
JP2004518629A
JP2007514704A
JP2007529484A
JP2006522127A

US3507961
US2588968
GB1176288B
WO1999024461A1
WO2003080576A1
GB2245565A
WO2005046601A1
WO2005090353A1
WO2004087652A1

BIERE,H. et al.,Blood glucose lowering sulfonamides with asymmetric carbon atoms. 2,Journal of Medicinal Chemistry,1974年,Vol.17, No.7,p.716-721

Yoshikazu Iwase
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yasufumi Shiroyama

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