Title:
治療化合物
Document Type and Number:
Japanese Patent JP2010518108
Kind Code:
A
Abstract:
The invention provides compounds of Formula (I): herein R1 and R2 have any of the values or specific values defined herein, as well as compositions comprising such compounds and therapeutic methods comprising the administration of such compounds, having anti-cancer activity.
Inventors:
Hammond, Gerald Bee.
Su, Bo
Bates, Paula Jay.
Su, Bo
Bates, Paula Jay.
Application Number:
JP2009549221A
Publication Date:
May 27, 2010
Filing Date:
February 06, 2008
Export Citation:
Assignee:
University of Louisville Research Foundation, Incorporated
Hammond, Gerald Bee.
Su, Bo
Bates, Paula Jay.
Hammond, Gerald Bee.
Su, Bo
Bates, Paula Jay.
International Classes:
C07C33/42; A61K31/045; A61K31/085; A61K31/19; A61K31/22; A61K31/235; A61K31/27; A61K31/357; A61P7/06; A61P19/00; A61P25/18; A61P35/00; A61P35/02; A61P43/00; C07C33/44; C07C33/48; C07C43/225; C07C57/52; C07C69/145; C07C69/767; C07C271/16; C07D317/20
Domestic Patent References:
| JP2007153792A | 2007-06-21 | |||
| JP2004525151A | 2004-08-19 | |||
| JPH07258255A | 1995-10-09 | |||
| JPS51125020A | 1976-11-01 | |||
| JPS51125020A | 1976-11-01 |
Foreign References:
| US6387901B1 | 2002-05-14 | |||
| DE10029709A1 | 2002-01-03 | |||
| US6387901B1 | 2002-05-14 | |||
| DE10029709A1 | 2002-01-03 |
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JPN6013017281; Ｓｙｎｔｈｅｓｉｓ （５）, 2006, ８０３-８０６
JPN6013017283; Ｊｏｕｒｎａｌ ｏｆ Ｆｌｕｏｒｉｎｅ Ｃｈｅｍｉｓｔｒｙ ４８, 1990, １２３-１３１
JPN6013017286; Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ ６５（１３）, 2000, ４２１７-４２２１
JPN6013017288; Ｂｕｌｌｅｔｉｎ ｄｅ ｌａ Ｓｏｃｉｅｔｅ Ｃｈｉｍｉｑｕｅ ｄｅ Ｆｒａｎｃｅ （３）, 1969, ９１１-１４
JPN6013017291; Ｚｈｕｒｎａｌ Ｏｒｇａｎｉｃｈｅｓｋｏｉ Ｋｈｉｍｉｉ ２８（９）, 1992, １８５４-６１
JPN6013017292; Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ ７２, 2007, ５９０１-５９０４
JPN6013017293; Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ ６０, 1995, ７４９６-７５０２
JPN6013017294; Ｓｙｎｔｈｅｔｉｃ Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ ２４（１５）, 1994, ２１３３-２１３８
JPN6013017295; Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｏｍｅｔａｌｌｉｃ Ｃｈｅｍｉｓｔｒｙ １６５（２）, 1979, Ｃ２８-Ｃ３２
JPN6013017296; Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ ２２（５１）, 1981, ５１５３-５１５６
JPN6013017297; Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ ３１（２６）, 1990, ３６９９-３７０２
JPN6013017298; Ｔｅｔｒａｈｅｄｒｏｎ ４６（１５）, 1990, ５２３０-５２３６
JPN6013017299; Ｃａｎａｄｉａｎ Ｊｏｕｒｎａｌ ｏｆ Ｃｈｅｍｉｓｔｒｙ ６５（１）, 1987, ４３-５５
JPN6013017300; Ａｎｎａｌｅｓ ｄｅ Ｃｈｉｍｉｅ （Ｐａｒｉｓ， Ｆｒａｎｃｅ） ３（６）, 1968, ５２９-４１
JPN6013017281; Ｓｙｎｔｈｅｓｉｓ （５）, 2006, ８０３-８０６
JPN6013017283; Ｊｏｕｒｎａｌ ｏｆ Ｆｌｕｏｒｉｎｅ Ｃｈｅｍｉｓｔｒｙ ４８, 1990, １２３-１３１
JPN6013017286; Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ ６５（１３）, 2000, ４２１７-４２２１
JPN6013017288; Ｂｕｌｌｅｔｉｎ ｄｅ ｌａ Ｓｏｃｉｅｔｅ Ｃｈｉｍｉｑｕｅ ｄｅ Ｆｒａｎｃｅ （３）, 1969, ９１１-１４
JPN6013017291; Ｚｈｕｒｎａｌ Ｏｒｇａｎｉｃｈｅｓｋｏｉ Ｋｈｉｍｉｉ ２８（９）, 1992, １８５４-６１
JPN6013017292; Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ ７２, 2007, ５９０１-５９０４
JPN6013017293; Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ ６０, 1995, ７４９６-７５０２
JPN6013017294; Ｓｙｎｔｈｅｔｉｃ Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ ２４（１５）, 1994, ２１３３-２１３８
JPN6013017295; Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｏｍｅｔａｌｌｉｃ Ｃｈｅｍｉｓｔｒｙ １６５（２）, 1979, Ｃ２８-Ｃ３２
JPN6013017296; Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ ２２（５１）, 1981, ５１５３-５１５６
JPN6013017297; Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ ３１（２６）, 1990, ３６９９-３７０２
JPN6013017298; Ｔｅｔｒａｈｅｄｒｏｎ ４６（１５）, 1990, ５２３０-５２３６
JPN6013017299; Ｃａｎａｄｉａｎ Ｊｏｕｒｎａｌ ｏｆ Ｃｈｅｍｉｓｔｒｙ ６５（１）, 1987, ４３-５５
JPN6013017300; Ａｎｎａｌｅｓ ｄｅ Ｃｈｉｍｉｅ （Ｐａｒｉｓ， Ｆｒａｎｃｅ） ３（６）, 1968, ５２９-４１
JPN6013017283; Ｊｏｕｒｎａｌ ｏｆ Ｆｌｕｏｒｉｎｅ Ｃｈｅｍｉｓｔｒｙ ４８, 1990, １２３-１３１
JPN6013017286; Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ ６５（１３）, 2000, ４２１７-４２２１
JPN6013017288; Ｂｕｌｌｅｔｉｎ ｄｅ ｌａ Ｓｏｃｉｅｔｅ Ｃｈｉｍｉｑｕｅ ｄｅ Ｆｒａｎｃｅ （３）, 1969, ９１１-１４
JPN6013017291; Ｚｈｕｒｎａｌ Ｏｒｇａｎｉｃｈｅｓｋｏｉ Ｋｈｉｍｉｉ ２８（９）, 1992, １８５４-６１
JPN6013017292; Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ ７２, 2007, ５９０１-５９０４
JPN6013017293; Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ ６０, 1995, ７４９６-７５０２
JPN6013017294; Ｓｙｎｔｈｅｔｉｃ Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ ２４（１５）, 1994, ２１３３-２１３８
JPN6013017295; Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｏｍｅｔａｌｌｉｃ Ｃｈｅｍｉｓｔｒｙ １６５（２）, 1979, Ｃ２８-Ｃ３２
JPN6013017296; Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ ２２（５１）, 1981, ５１５３-５１５６
JPN6013017297; Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ ３１（２６）, 1990, ３６９９-３７０２
JPN6013017298; Ｔｅｔｒａｈｅｄｒｏｎ ４６（１５）, 1990, ５２３０-５２３６
JPN6013017299; Ｃａｎａｄｉａｎ Ｊｏｕｒｎａｌ ｏｆ Ｃｈｅｍｉｓｔｒｙ ６５（１）, 1987, ４３-５５
JPN6013017300; Ａｎｎａｌｅｓ ｄｅ Ｃｈｉｍｉｅ （Ｐａｒｉｓ， Ｆｒａｎｃｅ） ３（６）, 1968, ５２９-４１
JPN6013017281; Ｓｙｎｔｈｅｓｉｓ （５）, 2006, ８０３-８０６
JPN6013017283; Ｊｏｕｒｎａｌ ｏｆ Ｆｌｕｏｒｉｎｅ Ｃｈｅｍｉｓｔｒｙ ４８, 1990, １２３-１３１
JPN6013017286; Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ ６５（１３）, 2000, ４２１７-４２２１
JPN6013017288; Ｂｕｌｌｅｔｉｎ ｄｅ ｌａ Ｓｏｃｉｅｔｅ Ｃｈｉｍｉｑｕｅ ｄｅ Ｆｒａｎｃｅ （３）, 1969, ９１１-１４
JPN6013017291; Ｚｈｕｒｎａｌ Ｏｒｇａｎｉｃｈｅｓｋｏｉ Ｋｈｉｍｉｉ ２８（９）, 1992, １８５４-６１
JPN6013017292; Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ ７２, 2007, ５９０１-５９０４
JPN6013017293; Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ ６０, 1995, ７４９６-７５０２
JPN6013017294; Ｓｙｎｔｈｅｔｉｃ Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ ２４（１５）, 1994, ２１３３-２１３８
JPN6013017295; Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｏｍｅｔａｌｌｉｃ Ｃｈｅｍｉｓｔｒｙ １６５（２）, 1979, Ｃ２８-Ｃ３２
JPN6013017296; Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ ２２（５１）, 1981, ５１５３-５１５６
JPN6013017297; Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ ３１（２６）, 1990, ３６９９-３７０２
JPN6013017298; Ｔｅｔｒａｈｅｄｒｏｎ ４６（１５）, 1990, ５２３０-５２３６
JPN6013017299; Ｃａｎａｄｉａｎ Ｊｏｕｒｎａｌ ｏｆ Ｃｈｅｍｉｓｔｒｙ ６５（１）, 1987, ４３-５５
JPN6013017300; Ａｎｎａｌｅｓ ｄｅ Ｃｈｉｍｉｅ （Ｐａｒｉｓ， Ｆｒａｎｃｅ） ３（６）, 1968, ５２９-４１
Attorney, Agent or Firm:
Hiroshi Kobayashi
Eiji Katayama
Norio Omori
Yasuhito Suzuki
Eiji Katayama
Norio Omori
Yasuhito Suzuki