THERAPEUTICAL NOVEL SUBSTITUTED (4,2,0)BICYCLOOCTANE DERIVATIVE

Japanese Patent JPS6379846

A

Compounds useful in treating cardiovascular disorders such as thrombosis, hypertension and atherosclerosis , in inhibiting gastric acid secretion and in preventing and treating peptic and intestinal ulcers, are depicted in formulas (1), (2) and (3) : wherein: A is -C IDENTICAL C-, trans -HC=CH- , -CH2CH2- or -CH=CHCH2- ; X is lower alkoxy, hydroxy, or (2,2,2)-trifluoroethoxy; Y is hydrogen, exo-(lower alkyl) or endo-(lower alkyl); n is an integer of 2-4; R1 is -CH2OH, -CHO, -CO2R or -CO2H, and the olefin formed by the R1(CH2)nCH= moiety is either (E) or (Z); R2 is hydrogen or methyl, or optionally -CH=CH2 when A is -CH=CHCH2-; and R3 is linear or branched alkyl, alkenyl or alkynyl having 5-10 carbon atoms, , -(CH2)m-phenyl or CH2O-phenyl; in which each phenyl may be optionally substituted with lower alkyl, lower alkoxy, trifluoromethyl, or halogen; in which: a is an integer of 0, 1 or 2; b is an integer of 3-7; m is an integer of 0, 1 or 2; and R is wherein X is - @-CH3, -NH@CH3 , - @-C6H5, -NH@-C6H5, or -NH @N(R4)2; in which each R4 is independently hydrogen or lower alkyl having 1-6 carbon atoms, and the pharmaceutically acceptable, non-toxic salts and esters thereof.

HEREN IEN FUI UU
UORUTAA KAATSU

JP21000787A

April 09, 1988

August 24, 1987

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SYNTEX INC

C07C27/00; C07C35/31; C07C35/52; C07C41/00; C07C43/196; C07C43/23; C07C45/00; C07C45/29; C07C45/30; C07C45/45; C07C45/59; C07C45/71; C07C45/78; C07C47/267; C07C47/27; C07C47/273; C07C47/277; C07C59/46; C07C59/54; C07C59/62; C07C59/72; C07C67/00; C07C69/732; C07C231/00; C07C231/12; C07C233/25; C07C235/64; C07C275/28; (IPC1-7): C07C35/31; C07C35/52; C07C43/196; C07C43/23; C07C47/267; C07C59/46; C07C59/54; C07C59/62; C07C59/72; C07C69/732; C07C102/00; C07C103/38; C07C103/78; C07C127/19

Aoyama Aoi

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