ドキソルビシンを含む医薬の熱標的化送達 - THE UNIVERSITY OF MISSISSIPPI MEDICAL CENTER

Title:

ドキソルビシンを含む医薬の熱標的化送達

Document Type and Number:

Japanese Patent JP2009528984

Kind Code:

A

Abstract:

Elastin-like polypeptide (ELP) serves as a vector for thermally-targeted delivery of therapeutics, including cytotoxic chemotherapeutic drugs such as doxorubicin. Examples of an ELP-based delivery vehicle can comprise: (1) a cell penetrating peptide, such as a Tat peptide, (2) ELP, and (3) the lysosomally degradable glycylphenylalanylleucylglycine (GFLG) (SEQ ID NO: 3) spacer and a cysteine residue (SEQ ID NO: 4) conjugated to therapeutic such as doxorubicin, or an analog thereof.

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Inventors:

Rocher, Dresen
Bidwell The Third, Jean
Pribe, Waldemar
Foct, Isabella

Application Number:

JP2008552614A

Publication Date:

August 13, 2009

Filing Date:

January 29, 2007

Export Citation:

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Assignee:

THE UNIVERSITY OF MISSISSIPPI MEDICAL CENTER

International Classes:

A61K47/48; A61K31/337; A61K31/475; A61K31/519; A61K31/704; A61K47/42; A61P35/00; C07K7/04; C07K14/00; C07K14/155

Foreign References:

US20040234497A1	2004-11-25
US20030124742A1	2003-07-03
WO2006001806A2	2006-01-05

Attorney, Agent or Firm:

Shintaro Nogawa

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