Title:
Those use in a condensation cyclo Octine compound and a non-metal click reaction
Document Type and Number:
Japanese Patent JP5920936
Kind Code:
B2
Abstract:
The invention relates to fused cyclooctyne compounds, and to a method for their preparation. The invention also relates to a conjugate wherein a fused cyclooctyne compound according to the invention is conjugated to a label, and to the use of these conjugates in bioorthogonal labeling, imaging and/or modification, such as for example surface modification, of a target molecule. The invention further relates to a method for the modification of a target molecule, wherein a conjugate according to the invention is reacted with a compound comprising a 1,3-dipole or a 1,3-(hetero)diene.
Inventors:
Van der ft, floris, lewis
Lute Jess, Floris Petrus Johannes Theodorus
Don Melholt, Frederick, Jean
Lute Jess, Floris Petrus Johannes Theodorus
Don Melholt, Frederick, Jean
Application Number:
JP2013507899A
Publication Date:
May 18, 2016
Filing Date:
April 26, 2011
Export Citation:
Assignee:
Shinafix B.V.
International Classes:
C07C33/16; A61K49/00; A61K51/00; C07C29/00; C07C29/58; C07C271/16; C07D495/04
Domestic Patent References:
| JP2014511371A |
Other References:
Jan Dommerholt, et al.,Angew. Chem. Int. Ed.,2010年,Vol.49,pp.9422-9425
Christina Antony-Mayer, et al.,Chem. Ber.,1998年,Vol.121,pp.2013-2018
Herbert Meier, et al.,Liebigs Ann. chem.,1987年,pp.1087-1094
Heiner Detert, et al.,Liebigs Ann. Recueil,1997年,pp.1565-1570
Von Herbert Meier, et al,Angew. Chem.,1981年,Vol.93, Nr.3,pp.286-287
Christina Antony-Mayer, et al.,Chem. Ber.,1998年,Vol.121,pp.2013-2018
Herbert Meier, et al.,Liebigs Ann. chem.,1987年,pp.1087-1094
Heiner Detert, et al.,Liebigs Ann. Recueil,1997年,pp.1565-1570
Von Herbert Meier, et al,Angew. Chem.,1981年,Vol.93, Nr.3,pp.286-287
Attorney, Agent or Firm:
Ikeda adult
Kazuhiro Yamaguchi
Masakazu Noda
Kazuhiro Yamaguchi
Masakazu Noda