Ti-2 PROTEIN DERIVED FROM TRIATOMA INFESTANS HAVING BLOOD CLOTTING INHIBITION ACTIVITY

Title:

Ti-2 PROTEIN DERIVED FROM TRIATOMA INFESTANS HAVING BLOOD CLOTTING INHIBITION ACTIVITY

Document Type and Number:

Japanese Patent JP3648549

Kind Code:

B2

Abstract:

PROBLEM TO BE SOLVED: To provide a new protein having blood clotting inhibition activity.
SOLUTION: The present invention provides a Ti-2 protein which is a new protein derived from Triatoma infestans and provide a Ti-2 gene encoding the protein. The Ti-2 protein has blood clotting inhibition activity and, accordingly, pharmaceuticals containing the Ti-2 protein as an active component are useful as a blood clotting inhibition agent for the treatment and prevention of myocardial infarction, pulmonary infarction and cerebral infarction. The Ti-2 protein is highly expectable also in the field for the development of pharmaceuticals as a leading compound of a blood clotting inhibitor.

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Inventors:

Yasuo Shinzai
Masao Yuda
Haruhiko Izawa

Application Number:

JP2001317370A

Publication Date:

May 18, 2005

Filing Date:

October 15, 2001

Export Citation:

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Assignee:

Mie University

International Classes:

C12N15/09; A61K38/55; A61P7/02; A61P9/10; C07K14/435; (IPC1-7): C12N15/09; A61K38/55; A61P7/02; A61P9/10; C07K14/435

Domestic Patent References:

JP9067396A
JP2003116568A

Foreign References:

WO2000011172A1

Other References:

Proc. Natl. Acad. Sci. USA,1998年,95,p.14290-14295
Biochim. Biophys. Acta.,2000年,1482 [1-2],p.110-118
J. Biol. Chem.,2000年,275 [9],p.6636-6641

Attorney, Agent or Firm:

Kosaku Sugimura

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