PURPOSE: To provide a new tissue injury healing factor originated from human or animal tissue or blood component, increasing by the injury of human or animal tissue and active to promote the production of hepatocyte growth factor(HGF) of an HGF-producing cell.

CONSTITUTION: This new tissue injury healing factor indulin is originated from the tissue or blood component of human or animal, increases by the injury of human or animal tissue, exhibits a molecular weight of 10-30kD by the gel column treatment with biogel P-60 and Sephadex G-150 and a molecular weight of 40-60kD by SDS polyacrylamide electrophoresis under non-reducing condition and 10-20kD under reducing condition and is active to promote the production of hepatocyte growth factor (HGF) of an HGF-producing cell, stable by heat- treatment at 100°C for 5min, acid treatment at pH1.0, reducing treatment with 1mM dithiothreitol and heparinase treatment at 0.31mU/ml and 37°C for 1hr and inactivated by trypsin treatment at 100μg/ml and 37°C for 3hr.