Title:
【発明の名称】3‐および5‐置換1,2,3,4‐オキサトリアゾール‐5‐イミン化合物,その製造方法,前記化合物を含む医薬組成物,および薬物製造用の前記化合物の使用
Document Type and Number:
Japanese Patent JPH07509703
Kind Code:
A
Abstract:
3- and 5-substituted 1,2,3,4-oxatriazole-5-imine compounds of general formula (I) wherein R<1> is the same or different groups and represents alkyl or alkoxy groups having 1 to 3 carbon atoms, halogen, trifluoromethyl, nitro, cyano, phenyl or alkylsulphonyl groups, n is 1 to 3, X is -SO2 or -C(O)NH-, Y is -(CHR<2>)m-, wherein m = 1 to 4, and R<2> means -CH2-aryl, alkyl, hydrogen or a direct bond, and Q means 10-camphoryl, --C(O)O-alkyl, aryl, -SO2-alkyl or -SO2-aryl, are prepared by ring closing a 1-arylthiosemicarbazide derivative of general formula (II) wherein R<1> and n have the same meaning as in formula (I), by treatment with alkyl nitrite having 1 to 6 carbon atoms or alkali metal nitrite under acidic conditions at 0 to 10 DEG C, whereafter the resulting salts is converted into the corresponding free compound, which is subsequently reacted with a compound of the type C1SO2-Y-Q or O=C=N-Y-Q, wherein Y and Q have the same meaning as in formula (I).
Inventors:
Karp Gunner Leo
Priv shut Herbert Fritz
Pedersen Soren Bols
Coreltim varnish
Alede Bourges Ingvar Frisch
Priv shut Herbert Fritz
Pedersen Soren Bols
Coreltim varnish
Alede Bourges Ingvar Frisch
Application Number:
JP50490493A
Publication Date:
October 26, 1995
Filing Date:
July 08, 1993
Export Citation:
Assignee:
Acty Celsukab Gear Pharmaseutesk Fabric
International Classes:
A61K31/41; A61P7/02; A61P11/00; C07D273/00; C07D413/12; (IPC1-7): C07D273/00; A61K31/41; C07D413/12
Attorney, Agent or Firm:
Akihide Sugimura (1 outside)