Title:
【発明の名称】DP-1及びその他のDPタンパク質の阻害剤のアッセイ
Document Type and Number:
Japanese Patent JPH10502252
Kind Code:
A
Abstract:
PCT No. PCT/GB95/01567 Sec. 371 Date Feb. 26, 1996 Sec. 102(e) Date Feb. 26, 1996 PCT Filed Jul. 3, 1995 PCT Pub. No. WO96/01425 PCT Pub. Date Jan. 18, 1996The protein DP-1, part of the DP-1/E2F-1 transcription factor complex, as well as DP-2 and DP-3 has its phosphorylation level regulated during cell cycle progression. This finding allows assays to be based on changes in phosphorylation of DP proteins, in particular for agents which may affect the phosphorylation state of DP. DP-1 has been found to have a greater affinity to DNA when in a hypophosphorylated state. Antibodies that recognize phosphorylation sites on DP-1 are also disclosed.
Inventors:
La Sang, Nicholas Barry
Application Number:
JP50374596A
Publication Date:
March 03, 1998
Filing Date:
July 03, 1995
Export Citation:
Assignee:
Medical Research Council
International Classes:
C07K14/47; C12N15/02; C12P21/08; C12Q1/04; G01N33/53; (IPC1-7): C12Q1/04; C12N15/02; G01N33/53
Attorney, Agent or Firm:
Yusuke Hiraki (2 outside)