Title:
【発明の名称】弱毒インフルエンザウイルス
Document Type and Number:
Japanese Patent JP2002513575
Kind Code:
A
Abstract:
An attenuated influenza virus carrying a genomic nucleic acid segment which comprises 5' and 3' non-coding regions providing a mutated duplex region of an influenza virus RNA genomic segment operably-linked to a protein coding sequence for an influenza viral protein or a functional modification thereof, wherein said duplex region has at least one base-pair substitution such that expression of said protein-coding sequence in cells infected by said virus is reduced to give an attenuated phenotype. The attenuated influenza virus can be used in a vaccine.
Inventors:
Brownlee, George, Go
Fodor, Irvine
Paresse, peter
Garcia-Sustre, Adolfo
Fodor, Irvine
Paresse, peter
Garcia-Sustre, Adolfo
Application Number:
JP2000547239A
Publication Date:
May 14, 2002
Filing Date:
May 06, 1999
Export Citation:
Assignee:
Isis Innovation Limited
International Classes:
C12N15/09; A61K39/145; A61P31/16; C07K14/11; C12N5/10; C12N7/00; C12N7/04; C12N15/44; C12N15/86; (IPC1-7): C12N15/09; A61K39/145; A61P31/16; C12N5/10; C12N7/00
Attorney, Agent or Firm:
Yusuke Hiraki (1 person outside)