Title:
【発明の名称】ケモカインレセプターアンタゴニストとその使用方法
Document Type and Number:
Japanese Patent JP2000516210
Kind Code:
A
Abstract:
Disclosed is a method of treating a subject with a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to the subject a therapeutically effective amount of a compound represented by the following structural formula:and physiologically acceptable salts thereof.Z is a substituted or unsubstitured aromatic group.Y is a covalent bond, -O- or -CO-.n is an integer from one to about five.X is a covalent bond or -CO-.Ra is an aliphatic or a substituted aliphatic group; Rb is an aliphatic group substituted with an aromatic group or substituted aromatic group; and, taken together with the nitrogen atom bonded to Ra and Rb, can form a substituted or unsubstituted non-aromatic heterocyclic ring.
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Inventors:
Schwender, Charles, F.
McKay, Charles, Earl.
Pinto, Julia, Sea.
Newman, Walter
McKay, Charles, Earl.
Pinto, Julia, Sea.
Newman, Walter
Application Number:
JP50618898A
Publication Date:
December 05, 2000
Filing Date:
July 11, 1997
Export Citation:
Assignee:
Leuco Site, Incorporated
International Classes:
C07D295/08; A61K31/047; A61K31/05; A61K31/133; A61K31/135; A61K31/137; A61K31/14; A61K31/216; A61K31/222; A61K31/235; A61K31/404; A61K31/423; A61K31/428; A61K31/451; A61K31/4535; A61K31/454; A61K31/495; A61K31/496; A61K31/55; A61P1/04; A61P11/06; A61P17/06; A61P19/02; A61P37/02; C07D209/14; C07D211/52; C07D263/56; C07D277/26; C07D295/18; C07D409/06; C07D409/14; (IPC1-7): A61K31/133; A61K31/047; A61K31/135; A61K31/14; A61K31/235; A61K31/404; A61K31/423; A61K31/428; A61K31/451; A61K31/495; A61K31/55; A61P1/04; A61P11/06; A61P17/06; A61P19/02; A61P37/02; C07D211/52; C07D263/56; C07D295/08; C07D295/18
Attorney, Agent or Firm:
Yoshinori Hosoda