Title:
【発明の名称】ケトンとシラン剤/金属化合物/キラルリガンド系とのエナンチオ選択的還元
Document Type and Number:
Japanese Patent JP2001515875
Kind Code:
A
Abstract:
A process for the enantioselective reduction of prochiral ketones to chiral alcohols by (a) the reaction of a prochiral ketone with a silane agent, which is present in a stoichiometric quantity, in the presence of a catalyst derived from a Zn, Co or Cd precursor compound and from a chiral amine, imine, alcohol or amino alcohol ligand; (b) the hydrolysis of the siloxane obtained using an appropriate agent; and (c) the separation and purification of the optically active alcohol formed. Polymethylhydrosiloxane (PMHS) is a preferred silane agent, zinc is a preferred metal, and the precursor compound is produced by reacting a salt or complex of the respective metal with the reducing agent. In another embodiment, an appropriate salt of the chosen metal is used directly in the reaction with the chiral ligand to produce the catalytic form after reaction with the ligand. The process enables high enantiomeric excesses (ee) to be obtained in chiral alcohols.
Inventors:
Hubert Mimun
Application Number:
JP2000510691A
Publication Date:
September 25, 2001
Filing Date:
September 03, 1998
Export Citation:
Assignee:
Firmenich SA
International Classes:
C07D295/12; B01J31/00; B01J31/18; B01J31/22; C07B53/00; C07C29/14; C07C29/143; C07C29/147; C07C33/20; C07C211/09; C07C211/18; C07C217/08; C07C251/16; C07C251/18; C07C251/24; C07D207/08; C07D209/44; C07D307/42; C07D317/58; C07D453/04; C07D471/22; C07F3/06; (IPC1-7): C07C29/143; B01J31/22; C07B53/00; C07C33/20; C07C211/09; C07C211/18; C07C217/08; C07C251/16; C07C251/18; C07C251/24; C07D207/08; C07D209/44; C07D295/12; C07D307/42; C07D317/58; C07D453/04; C07D471/22; C07F3/06
Attorney, Agent or Firm:
Toshio Yano (3 outside)
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