Title:
【発明の名称】ヘテロ環置換アルコキシクマリン、その製造方法およびこれを含有する治療剤
Document Type and Number:
Japanese Patent JP2875557
Kind Code:
B2
Abstract:
Heterocyclically substituted alkoxycoumarins of the formula
in which
R<1> and R<2> are, independently of one another, hydrogen, C1- to C5-alkyl, trifluoromethyl, phenyl, halogen or together are a C3- to C5-alkylene chain; furthermore
R<3> is C1- to C5-alkyl or halogen;
n is an integer from 0 to 3;
R<4> is hydrogen or C1- to C4-alkyl and
Het is one of the following heterocycles:
with the following meanings for the symbols used:
X is oxygen or sulphur;
R<5> is optionally C1-C4-alkoxy-substituted C1-C10-alkyl, 5-6-membered oxacycloalkyl, C3-C7-cycloalkyl, benzyl, an optionally halogen- or NO2-substituted phenyl radical, a pyridine ring, C1-C5-alkoxycarbonyl, perfluoro-C1-C2-alkyl;
R<6> is C1-C5-alkyl, C1-C5-alkoxy;
R<7> is C1-C5-alkyl, an optionally halogen-substituted benzyl radical, halogen; m is 0 to 2;
R<8> is C1-C5-alkyl, C3-C6-cycloalkyl, benzyl, phenyl;
R<9> is hydrogen, C1-C4-alkyl;
R<10> is C1-C5-alkyl, C3-C6-cycloalkyl;
R<11> is C1-C5-alkyl;
R<12> is hydrogen, C1-C5-alkyl, C3-C6-cycloalkyl;
R<13> is C1-C5-alkyl, halogen, p = 0 to 2;
R<14> is C1-C5-alkyl, q = 0 or 1;
R<15>, R<16> are hydrogen, C1-C5-alkyl, benzyl;
R<17> is hydrogen, C1-C5-alkyl;
R<18> is C1-C5-alkyl
with the proviso that R<5> is not phenyl when X is oxygen, R<1> is methyl and R<2> to R<4> are hydrogen, method for their preparation and medicaments prepared therefrom.
Inventors:
FURITSUTSUUFURIIDERU FURITSUKERU
TOOMASU KYUTSUKENHEENAA
BEATORISU RENDENBATSUHAAMYURAA
HAARARUTO UAIFUENBATSUHA
HANSUUYURUGEN TETSUSHENDORUFU
TOOMASU KYUTSUKENHEENAA
BEATORISU RENDENBATSUHAAMYURAA
HAARARUTO UAIFUENBATSUHA
HANSUUYURUGEN TETSUSHENDORUFU
Application Number:
JP26534389A
Publication Date:
March 31, 1999
Filing Date:
October 13, 1989
Export Citation:
Assignee:
BEE AA ESU EFU AG
International Classes:
A61K31/335; A61K31/35; A61K31/40; A61K31/41; A61K31/44; A61K31/443; A61K31/4433; A61K31/445; A61K31/47; A61P25/00; C07D405/12; C07D407/12; C07D409/12; C07D413/12; C07D417/12; C07D419/12; (IPC1-7): C07D405/12; A61K31/335; A61K31/41; A61K31/44; C07D407/12; C07D409/12; C07D413/12; C07D417/12
Attorney, Agent or Firm:
Tajiro Taiji