Title:
【発明の名称】ヒトSTAT4
Document Type and Number:
Japanese Patent JPH11503308
Kind Code:
A
Abstract:
The invention provides methods and compositions relating to interleukin 12 signal transducers, particularly an isolated human signal transducer and activator of transcription 4 (hStat 4), or a fragment thereof having an hStat 4-specific binding affinity, nucleic acids encoding hStat 4, which nucleic acids may be part of hStat 4-expression vectors and may be incorporated into a recombinant cell, agents which selectively bind hStat 4 or hStat 4 intracellular binding targets, or disrupt the binding of hStat 4 to such intracellular targets, methods of making such agents and hStat 4-specific binding targets in the form of cell surface proteins and nucleic acids. An hStat 4 drug screening assay involves forming mixtures of an hStat 4, an intracellular hStat 4 binding target, and a prospective agent at different concentrations. The mixtures are incubated to permit the binding of the intracellular hStat 4 binding target to the hStat 4 and the mixtures are then analyzed for the presence of such binding. A difference in such binding between the first and second mixtures indicates that the agent is capable of modulating the binding of hStat 4 to an intracellular hStat 4 binding target.
Inventors:
Hoi Timothy
Roth Michael
Roth Michael
Application Number:
JP52861796A
Publication Date:
March 26, 1999
Filing Date:
March 22, 1996
Export Citation:
Assignee:
Tularic Inc.
International Classes:
A61K38/43; A61K45/00; A61P37/04; C07K14/47; C07K14/715; C12N5/10; C12N15/09; G01N33/15; C12N15/12; C12Q1/68; G01N33/68; A61K38/00; (IPC1-7): C12N15/09; A61K38/43; A61K45/00; C07K14/47; C12N5/10; C12Q1/68; G01N33/15
Attorney, Agent or Firm:
Minoru Nakamura (7 outside)