Title:
【発明の名称】ヒストンデアセチラーゼ阻害剤による造血幹細胞への遺伝子形質導入の改良及び自己再生の促進
Document Type and Number:
Japanese Patent JP2002527101
Kind Code:
A
Abstract:
A method of promoting stem cell self-renewal is disclosed which comprises exposing a population of stem cells, particularly hematopoietic stem cells, to an effective dose of a histone deacetylase inhibitor, particularly trichostatin A, trapoxin, or chlamydocin. The invention is also directed to the use of histone deacetylase inhibitors to increase the number of transduced stem cells.
Inventors:
Ravau Catherine Pee
Young Judy Carroll
Hill Beth Louise
Young Judy Carroll
Hill Beth Louise
Application Number:
JP2000577279A
Publication Date:
August 27, 2002
Filing Date:
October 14, 1999
Export Citation:
Assignee:
Novartis Actien Gezel Shaft
International Classes:
C12N15/09; A61K35/12; A61K48/00; A61P7/00; A61P37/00; C12N5/0789; C12N5/10; C12R1/91; (IPC1-7): C12N5/06; A61K48/00; A61P7/00; A61P37/00; C12N5/10; C12N15/09
Attorney, Agent or Firm:
Masahiro Abe