Title:
【発明の名称】BZ83株の結合価を有する髄膜炎菌ワクチン
Document Type and Number:
Japanese Patent JP2001503068
Kind Code:
A
Abstract:
The invention concerns a pharmaceutical composition comprising (i) the subunit of least molecular weight (TbpB) of the human transferrin receptor (HTR) of a Neisseria meningitis strain having a DNA sequence coding for Tbp, (a) which contains two AvaII restriction sites, 3 HincII restriction sites, no VspI restriction site and no XhoI restriction site or (b) from which it is possible to generate by PCR (polymerase chain reaction) using primers P3 of formula 5'-AAGACCAAGGCGGATACGGTTTTGC-3' and P4 of formula 5'-GAAGACGAGTCGGAAACAAAGGGATG-3', a polynucleotide of 765 to 775 nucleotides. Such a strain is for example the BZ83 strain whereof the DNA sequence coding for TbpB is shown in the SEQ ID NO 1.
Inventors:
Quantan-Mille, Mary-Jose
Robbie, Bashula
Robbie, Bashula
Application Number:
JP51175699A
Publication Date:
March 06, 2001
Filing Date:
August 03, 1998
Export Citation:
Assignee:
Pasteur Merueu Serom e Vaksan
International Classes:
A61K39/00; A61K39/095; A61K48/00; A61P25/00; A61P31/04; C07K14/22; C12N1/21; C12Q1/68; C12N15/09; A61K38/00; C12R1/36; (IPC1-7): A61K48/00; A61K39/00; A61K39/095; A61P25/00; C12N1/21; C12N15/09; C12Q1/68
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)