Title:
【発明の名称】抗血栓性物質の固定化方法
Document Type and Number:
Japanese Patent JP3093375
Kind Code:
B2
Abstract:
An anti-thrombogenic substance is immobilized on a base of a medical device to impart anti-thrombogenic properties to the medical device. The method comprises the steps of applying a photo-reactive azide derivative macromolecular material to a base to form a bonding layer, coating the bonding layer with a macromolecular layer composed of a water-soluble photo-crosslinking macromolecular material containing the anti-thrombogenic substance, and irradiating the base with ultraviolet light with the bonding layer and the macromolecular layer formed thereon to develop inter-molecular covalent bonding in the bonding layer. The macromolecular layer containing the anti-thrombogenic substance is thus fixed onto the base. Concurrently, the anti-thrombogenic substance is immobilized in the macromolecular layer which is crosslinked. The azide derivative can be poly-m-azidostyrene, copolymers, of poly-m-aziodstyrene with styrene and copolymers of poly-m-azidostyrene with methyl methacrylate. The water-soluble photo-crosslinking macromolecular material can be a copolymer of a photo-dimeric monomer with a water-soluble monomer or a copolymer of a photo-reactive azide with a water-soluble monomer.
Inventors:
Takehisa Matsuda
Yasuhide Nakayama
Takashi Sugawara
Yasuhide Nakayama
Takashi Sugawara
Application Number:
JP28806291A
Publication Date:
October 03, 2000
Filing Date:
November 01, 1991
Export Citation:
Assignee:
Tokai Medical Products Co., Ltd.
International Classes:
A61L33/00; A61M25/00; C12N11/04; C12N11/08; (IPC1-7): A61L33/00; A61M25/00
Attorney, Agent or Firm:
Tsutomu Adachi