Title:
【発明の名称】ムスカリン性アンタゴニスト
Document Type and Number:
Japanese Patent JP3344997
Kind Code:
B2
Abstract:
Heterocyclic derivatives of di-N-substituted piperazine or 1,4 di-substituted piperidine compounds in accordance with formula (I) (including all isomers, salts and solvates), wherein one of Y and Z is -N- and the other is -N- or -CH-; X is -O-, -S-, -SO-, -SO2- or -CH2-; Q is (1), (2), (3); R is alkyl, cycloalkyl, optionally substituted aryl or heteroaryl; R<1>, R<2> and R<3> are H or alkyl; R<4> is alkyl, cyclolalkyl or (4); R<5> is H, alkyl, -C(O)alkyl, arylcarbonyl, -SO2alkyl, aryl-sulfonyl-C(O)Oalkyl, aryloxycarbonyl, -C(O)NH-alkyl or aryl-aminocarbonyl, wherein the aryl portion is optionally substituted; R<6> is H or alkyl; and R<7> is H, alkyl, hydroxyalkyl or alkoxyalkyl; are muscarinic antagonists useful for treating cognitive disorders such as Alzheimer's disease. Pharmaceutical compositions and methods of treatment are also disclosed.
Inventors:
Kozlowsky, Joseph A.
MacConby, Stuart W.
Tagat, Jayarang Earl.
Vice, Susan F.
MacConby, Stuart W.
Tagat, Jayarang Earl.
Vice, Susan F.
Application Number:
JP2000557249A
Publication Date:
November 18, 2002
Filing Date:
June 28, 1999
Export Citation:
Assignee:
Schering Corporation
International Classes:
A61K31/4427; A61K31/443; A61K31/4433; A61K31/4545; A61K31/496; A61K31/501; A61P25/28; A61P43/00; C07D401/12; C07D401/14; C07D405/14; C07D409/12; (IPC1-7): C07D401/12; A61K31/4545; A61K31/496; A61K31/501; A61P25/28; A61P43/00; C07D401/14; C07D405/14; C07D409/12
Other References:
【文献】国際公開96/26196(WO,A1)
Attorney, Agent or Firm:
Shusaku Yamamoto