Title:
【発明の名称】抗炎症/抗アレルギー剤用ナフタレンプロピオン酸誘導体
Document Type and Number:
Japanese Patent JPH06500997
Kind Code:
A
Abstract:
There are disclosed compounds of the formula wherein a is alkyl 3-19 carbon atoms, diloweralkyl allyl, diahaloallyl, diphenylallyl, lower alkynyl, W is -CR2O-, -CH=CH- or -CH=CHCH2O- X is N or CR; Z is R is hydrogen or lower alkyl; Y is R1 is hydrogen, lower alkyl or phenyl; R2 is hydrogen or lower alkyl; or R1 and R2 taken together form a benzene ring, optionally substituted by halo; R3 is -OR, - NHSO2R4; R4 is phenyl or loweralkyl substituted phenyl; R5 is halo; and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as alelrgic rhinitis, allergic bronchial asthma and the like, in psoriasis, ulcerative colitis, rheumatoid arthritis as well as in other immediate hypersensitivity reactions.
Inventors:
Cleft, Anthony Frank, The Third
Massen, John Henry
Bixler, James Jacob
Giverson, john william
Kubrak, Dennis Martin
Bunker, Annette Lee
Massen, John Henry
Bixler, James Jacob
Giverson, john william
Kubrak, Dennis Martin
Bunker, Annette Lee
Application Number:
JP51589091A
Publication Date:
January 27, 1994
Filing Date:
September 05, 1991
Export Citation:
Assignee:
American Home Products Corporation
International Classes:
A61K31/045; A61K31/085; A61K31/11; A61K31/12; A61K31/17; A61K31/42; A61K31/421; A61K31/423; A61K31/425; A61K31/426; A61K31/47; A61P29/00; A61P37/08; C07C27/02; C07C29/147; C07C33/24; C07C43/16; C07C43/23; C07C59/66; C07C59/68; C07C275/28; C07C311/10; C07D213/30; C07D215/14; C07D215/18; C07D235/12; C07D263/14; C07D263/56; C07D277/22; C07D277/24; C07D277/64; (IPC1-7): C07C33/24; A61K31/045; A61K31/085; A61K31/11; A61K31/12; A61K31/17; A61K31/42; A61K31/425; A61K31/47; C07C27/02; C07C29/147; C07C43/16; C07C43/23; C07C59/66; C07C275/28; C07C311/10; C07D213/30; C07D215/14; C07D235/12; C07D263/14; C07D263/56; C07D277/22; C07D277/24
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)