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Title:
STABILIZED POWDERY PHARMACEUTICAL COMPOSITION FOR APPLICATION TO NASAL MUCOUS MEMBRANE
Document Type and Number:
Japanese Patent JPS6032714
Kind Code:
A
Abstract:

PURPOSE: To provide the titled composition having low irritancy to the nasal mucous membrane and little ill odor, and composed of a lower alkyl ether of cellulose, beclomethasone dipropionate and an odorless solid organic acid as a stabilizer.

CONSTITUTION: A stabilized powdery drug composition for the application to the nasal mucous membrane, is prepared by compounding (A) a lower alkyl ether of cellulose (e.g. hydroxypropylcellulose) preferably having a water-content of 3W 9wt%, (B) beclomethasone dipropionate which is a steroidal anti-inflammatory agent, and (C) an odorless organic acid solid at normal temperature (e.g. stearic acid, palmitic acid, etc.) as a stabilizer. The particles having an effective particle diameter of about 20W250μ acount for preferably ≥90wt% of the composition. Dose for application: 5W200mg per dose. It is suitable for the treatment of allergic rhinitis, vasomotor rhinitis, etc.


Inventors:
SUZUKI YOSHIKI
IGURA HIROSHI
Application Number:
JP13946683A
Publication Date:
February 19, 1985
Filing Date:
August 01, 1983
Export Citation:
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Assignee:
TEIJIN LTD
International Classes:
A61K31/19; A61K9/00; A61K9/14; A61K31/195; A61K31/56; A61K31/57; A61K31/715; A61K47/12; A61K47/38; A61P27/16; (IPC1-7): A61K31/19; A61K31/56; A61K31/72
Attorney, Agent or Firm:
Maeda Junhiro