Title:
【発明の名称】パパインスーパーファミリーのシステインプロテアーゼの阻害による寄生虫病の治療
Document Type and Number:
Japanese Patent JP2002511491
Kind Code:
A
Abstract:
The present invention relates to compounds and pharmaceutical compositions which inhibit proteases, such as cysteine proteases. In particular, the present invention relates to compounds and pharmaceutical compositions which inhibit cysteine proteases of the papain superfamily. The compounds and pharmaceutical compositions of the present invention are useful for treating diseases, particularly parasitic diseases, which are mediated by such proteases. In particular, the present invention relates to a method of treating malaria by inhibiting the cysteine protease falcipain.
Inventors:
Scott Kevin Thompson
Daniel Frank Baber
Thaddeus Anthony Tomaszeck
David Graham Tu
Daniel Frank Baber
Thaddeus Anthony Tomaszeck
David Graham Tu
Application Number:
JP2000543587A
Publication Date:
April 16, 2002
Filing Date:
April 08, 1999
Export Citation:
Assignee:
SMITHKLINE BEECHAM CORPORATION
International Classes:
A61K31/27; A61K31/341; A61K31/40; A61K31/427; A61K31/4402; A61K31/4418; A61K31/4436; A61K31/4439; A61K31/501; A61K31/5375; A61P33/02; A61P33/06; A61P33/10; A61P33/12; C07C281/06; C07C311/29; C07D207/24; C07D207/273; C12N9/48; C07D213/56; C07D295/215; C07D307/22; C07D307/33; C07D409/12; C07D413/12; C07D417/12; C12N9/99; C07D207/26; (IPC1-7): A61K31/27; A61K31/341; A61K31/40; A61K31/427; A61K31/4402; A61K31/4436; A61K31/4439; A61K31/501; A61K31/5375; A61P33/02; A61P33/06; A61P33/10; A61P33/12; C07D207/24; C07D213/56; C07D307/33; C12N9/48; C12N9/99
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)